{"id":"W4414632805","doi":"10.1172/jci197100","title":"Clonal hematopoiesis driven by Dnmt3a mutations promotes metabolic disease development in mice","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Institutes of Health; Canadian Institutes of Health Research; Edward P. Evans Foundation","keywords":"Haematopoiesis; Mutation; Disease; Metabolic pathway; Metabolic disease; Metabolism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006247834,0.0005840834,0.0003414487,0.001444219,0.0003347729,0.0005795717,0.0005026521,0.0009422025,0.004850917],"category_scores_gemma":[0.0003027993,0.0004621338,0.0005120836,0.0003498753,0.0006012514,0.0004002547,0.0005232577,0.00182037,0.0008697763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005293791,"about_ca_system_score_gemma":0.0003885931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006422817,"about_ca_topic_score_gemma":0.001348965,"domain_scores_codex":[0.9994861,0.0001220857,0.0000549868,0.0001202948,0.0001173941,0.0000992265],"domain_scores_gemma":[0.9995167,0.00007117681,0.0001704121,0.00004920719,0.0000243512,0.0001681701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007808215,0.0004305406,0.001427079,0.0001344891,0.00004001714,0.0003492556,0.00007777799,0.0002222325,0.9892284,0.001482314,0.0005316938,0.005295528],"study_design_scores_gemma":[0.0007462912,0.003831613,0.03683885,0.0003302827,0.0002934494,0.004508875,0.0002395549,0.008167079,0.9163914,0.001864669,0.026726,0.00006184149],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9734825,0.004137146,0.01004797,0.0009341007,0.0001292464,0.0001885042,0.004206858,0.0007523727,0.006121266],"genre_scores_gemma":[0.9771833,0.003510972,0.008035159,0.0003886512,0.00006145175,0.0002916779,0.001958979,0.0001771542,0.008392537],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004850917,"threshold_uncertainty_score":0.01622796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03156500492022746,"score_gpt":0.350675772906966,"score_spread":0.3191107679867385,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}