{"id":"W4414649622","doi":"10.1016/j.ygyno.2025.04.262","title":"Should we advocate for the continued availability of actinomycin D to remain an essential first-line treatment for low-risk gestational trophoblastic neoplasia?","year":2025,"lang":"en","type":"article","venue":"Gynecologic Oncology","topic":"Gestational Trophoblastic Disease Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sunnybrook Health Science Centre; University of Toronto","funders":"","keywords":"Methotrexate; Gestational trophoblastic neoplasia; Regimen; Chorioepithelioma; Chemotherapy; Gestational trophoblastic disease; Trophoblastic neoplasm; Dactinomycin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006067084,0.0002656264,0.001244582,0.0006265461,0.001131827,0.002610881,0.001535757,0.007838522,0.01921326],"category_scores_gemma":[0.03142564,0.0002340225,0.001118126,0.0008535685,0.001977688,0.003986971,0.0008457204,0.007859532,0.003330953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001144245,"about_ca_system_score_gemma":0.007130058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006121606,"about_ca_topic_score_gemma":0.01364816,"domain_scores_codex":[0.9973657,0.001259915,0.0003141741,0.0003465161,0.0004614543,0.0002523743],"domain_scores_gemma":[0.9745568,0.0128658,0.00332367,0.001193658,0.004759853,0.003300119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.006259234,0.001194054,0.06430787,0.003146631,0.0008887316,0.002499914,0.0004953407,0.001144135,0.006181154,0.02249501,0.4020675,0.4893204],"study_design_scores_gemma":[0.001638594,0.001881379,0.0332003,0.006528325,0.0006925287,0.002400878,0.00256045,0.0007181757,0.001348186,0.02047361,0.9283446,0.000213007],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.01306054,0.04936306,0.001578564,0.9132924,0.009359299,0.0001051528,0.0004018946,0.0001523761,0.01268669],"genre_scores_gemma":[0.1397005,0.08989564,0.01651388,0.7080108,0.03146677,0.0003224734,0.0006410423,0.0001520872,0.01329682],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01921326,"threshold_uncertainty_score":0.06427473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04549348621183624,"score_gpt":0.3722108733287157,"score_spread":0.3267173871168795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}