{"id":"W4414653433","doi":"10.1001/jamanetworkopen.2025.34941","title":"Brain Frailty and Functional Outcomes After Thrombolysis for Acute Ischemic Stroke","year":2025,"lang":"en","type":"article","venue":"JAMA Network Open","topic":"Acute Ischemic Stroke Management","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto Western Hospital; University of British Columbia; University of Ottawa; McMaster University; University of Saskatchewan; University of Alberta; Population Health Research Institute; Health Sciences Centre; Ottawa Hospital; Sunnybrook Health Science Centre; Kelowna General Hospital; University of Manitoba; University of Calgary","funders":"","keywords":"Thrombolysis; Neuroimaging; Cohort; Stroke (engine); Cohort study; White matter; Ischemic stroke; Brain ischemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004108263,0.0002149141,0.0005155098,0.00007197401,0.0001127198,0.0001394781,0.0002197752,0.000139219,0.0004442683],"category_scores_gemma":[0.0001115086,0.0001781982,0.0001454852,0.0002029139,0.00006585685,0.0001896993,0.0007706783,0.0001997993,0.00002037168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007586267,"about_ca_system_score_gemma":0.00007075648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002129852,"about_ca_topic_score_gemma":0.00001285499,"domain_scores_codex":[0.9986804,0.00002539291,0.000299392,0.0004494322,0.0001902521,0.0003551677],"domain_scores_gemma":[0.9990005,0.0003081005,0.00008349841,0.0004381939,0.00007521511,0.00009445229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009048953,0.00003994772,0.1659945,0.00004179735,0.001807501,0.000009694343,0.00003441786,0.000009901128,0.000464861,0.0003085281,0.8233181,0.007065913],"study_design_scores_gemma":[0.003902516,0.00005097996,0.4659992,0.0001319537,0.0009164379,0.000005817637,0.00007637318,0.0004676522,0.000225321,0.000133731,0.5279353,0.0001547303],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7238733,0.0009379872,0.01934119,0.0969516,0.0007825159,0.003588982,0.0001553549,0.0001178044,0.1542512],"genre_scores_gemma":[0.6613413,0.0001071678,0.02259327,0.04670282,0.0007967693,0.001225258,0.000284229,0.00005305588,0.2668961],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3000047,"threshold_uncertainty_score":0.7266713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01967159668190018,"score_gpt":0.310026660129174,"score_spread":0.2903550634472738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}