{"id":"W4414657969","doi":"10.1101/2025.09.26.678914","title":"BIN1 overexpression rescues cardiac but not skeletal muscle defects in a mouse model of caveolinopathy","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Caveolin-1 and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Agence Nationale de la Recherche","keywords":"Skeletal muscle; Cardiac muscle; Myofibril; Knockout mouse; Gene; Gene expression; Myocyte","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004248279,0.0005529852,0.0006837121,0.0002657437,0.00007152736,0.00005341747,0.0005765652,0.0009172442,0.000004149196],"category_scores_gemma":[0.0002559071,0.0006065025,0.0003403866,0.0002358103,0.00009474823,0.00001143345,0.001041862,0.0005363027,0.000004150034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001366223,"about_ca_system_score_gemma":0.001007327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002009711,"about_ca_topic_score_gemma":0.00001541448,"domain_scores_codex":[0.997281,0.0001360301,0.0006167141,0.001121112,0.0003356792,0.0005095284],"domain_scores_gemma":[0.9976853,0.00002392997,0.0003449714,0.001372481,0.0004084552,0.0001648454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008088123,0.0001751959,0.001452905,0.0009405201,0.00007639093,0.000007154413,0.00001159205,0.001667285,0.9954322,0.00005716412,0.00009520569,0.000003502338],"study_design_scores_gemma":[0.0005351112,0.00006741045,0.001817851,0.000478898,0.00006528303,5.98752e-9,0.000005071337,0.0009578237,0.9948568,0.00000300918,0.0006185127,0.0005941677],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941357,0.002772487,0.0007774451,0.0000222972,0.0003226805,0.0005390856,0.00133611,0.00006176025,0.00003243079],"genre_scores_gemma":[0.9965383,0.001564132,0.001157282,0.00008549121,0.0002606757,0.0001590344,0.000005784528,0.00008131369,0.0001479598],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002402622,"threshold_uncertainty_score":0.9996386,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009848701106772868,"score_gpt":0.2161726680940334,"score_spread":0.2063239669872605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}