{"id":"W4414674166","doi":"10.1016/j.ahj.2025.107283","title":"Mavacamten in symptomatic adolescent patients with obstructive hypertrophic cardiomyopathy: design of the phase 3 SCOUT-HCM trial","year":2025,"lang":"en","type":"article","venue":"American Heart Journal","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Bristol-Myers Squibb","keywords":"Phase (matter); MEDLINE; Clinical trial; Electrocardiography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002495027,0.001078235,0.001557758,0.0002110128,0.0004418445,0.0008347025,0.0005710734,0.001184472,0.003601742],"category_scores_gemma":[0.00161035,0.0003773164,0.001398058,0.000269975,0.0006210627,0.0006755128,0.0003682556,0.001901946,0.0004625559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005049666,"about_ca_system_score_gemma":0.001416388,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006072804,"about_ca_topic_score_gemma":0.001775342,"domain_scores_codex":[0.9994065,0.0003706925,0.00003326816,0.00006823656,0.00004171051,0.00007962477],"domain_scores_gemma":[0.9991084,0.0001755921,0.000217777,0.00007085664,0.00008206457,0.0003454319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9414455,0.01646953,0.009576793,0.0009335574,0.001370556,0.0001660743,0.0001928554,0.0006828923,0.004972046,0.0003293862,0.002265743,0.02159498],"study_design_scores_gemma":[0.8693679,0.1151815,0.01161436,0.00008433082,0.0006048168,0.0001217734,0.00005975054,0.0006354782,0.0004241253,0.0002513671,0.001636478,0.00001816396],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.9859962,0.00292389,0.0004625408,0.0005683129,0.0001911099,0.007236136,0.0008810908,0.00004182402,0.001698951],"genre_scores_gemma":[0.9792506,0.001910133,0.002150487,0.001285642,0.0003648981,0.01252667,0.001401776,0.00001895203,0.001090951],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.003601742,"threshold_uncertainty_score":0.0131951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01629166936034251,"score_gpt":0.2884712112114334,"score_spread":0.2721795418510909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}