{"id":"W4414681858","doi":"10.1101/2025.09.29.679187","title":"Development of a genetically encoded and potent PDE6D inhibitor","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Fonds Wetenschappelijk Onderzoek; Fonds National de la Recherche Luxembourg","keywords":"Prenylation; Small molecule; Plasma protein binding; HEK 293 cells; Chemical biology; Binding site; Membrane protein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002261832,0.0003836983,0.0003276333,0.0002555143,0.0001440991,0.000318092,0.000387577,0.0003803195,0.001258143],"category_scores_gemma":[0.0001532764,0.0001871566,0.00032234,0.0001716309,0.0001953302,0.0001895053,0.0002857715,0.0007135509,0.0007465219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003718379,"about_ca_system_score_gemma":0.0002391618,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005214193,"about_ca_topic_score_gemma":0.0004884364,"domain_scores_codex":[0.9998559,0.00001439261,0.00002161022,0.00003339752,0.00005240595,0.00002233988],"domain_scores_gemma":[0.9999204,0.00001256359,0.00001728964,0.00001247834,0.00001392065,0.00002333515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004243164,0.0000336355,0.00005153552,0.0000351424,0.000006419325,0.00003128078,0.000005884651,0.0002104183,0.9976761,0.0001500852,0.0000607822,0.001696317],"study_design_scores_gemma":[0.00001295673,0.0001163129,0.0001564733,0.000002066694,0.000009593169,0.0000756967,0.000001937736,0.0006290028,0.9961511,0.0000136557,0.002828717,0.000002431005],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9342365,0.004352219,0.05052942,0.0003758556,0.0001594515,0.0003486368,0.002488686,0.0005539457,0.006955233],"genre_scores_gemma":[0.9520429,0.002266137,0.03474099,0.0001276704,0.00002455411,0.0001361044,0.002791442,0.0001131096,0.007757052],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001258143,"threshold_uncertainty_score":0.004208863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008932439506357892,"score_gpt":0.212441058633363,"score_spread":0.2035086191270051,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}