{"id":"W4414681858","doi":"10.1101/2025.09.29.679187","title":"Development of a genetically encoded and potent PDE6D inhibitor","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Fonds Wetenschappelijk Onderzoek; Fonds National de la Recherche Luxembourg","keywords":"Prenylation; Small molecule; Plasma protein binding; HEK 293 cells; Chemical biology; Binding site; Membrane protein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002486095,0.0002973609,0.0002887846,0.0001104897,0.00008584336,0.00003866988,0.0001711238,0.0004533999,0.000007927395],"category_scores_gemma":[0.00007951543,0.0003030497,0.00008001347,0.0001089937,0.00009857545,0.000003151653,0.0005346953,0.0001738186,0.000002716278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004543521,"about_ca_system_score_gemma":0.0006608855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004348576,"about_ca_topic_score_gemma":0.000002649472,"domain_scores_codex":[0.998444,0.00005533445,0.0004903163,0.0006072274,0.0001829111,0.0002201935],"domain_scores_gemma":[0.9987898,0.000008619682,0.0002332553,0.0005351694,0.0003034812,0.0001296235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005870901,0.00007547391,0.001034098,0.000342884,0.0001296491,0.000001783052,0.000009337566,0.00005561756,0.9980273,0.00009554681,0.0001438866,0.00002577496],"study_design_scores_gemma":[0.0003921945,0.00004175794,0.02629267,0.0002464874,0.00004218372,1.085582e-8,0.000002242874,0.0001433864,0.9512666,9.336848e-7,0.02125216,0.0003193448],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899662,0.001387965,0.007454028,0.0000683023,0.0006336447,0.0003667333,0.00006348801,0.00003725267,0.00002245389],"genre_scores_gemma":[0.970002,0.0002822921,0.02928071,0.0001158143,0.0001732465,0.00007016637,0.00000189005,0.00002760206,0.00004627383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04676062,"threshold_uncertainty_score":0.9999422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008932439506357892,"score_gpt":0.212441058633363,"score_spread":0.2035086191270051,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}