{"id":"W4414689663","doi":"10.1101/2025.09.29.679391","title":"AID/APOBEC3 Dynamic Catalytic Pockets and AID-α7 Regulation Mechanisms","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Machine Learning in Healthcare","field":"Computer Science","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of Toronto","funders":"","keywords":"Catalysis; Molecular dynamics; Enzyme; Destabilisation; Dynamics (music); Protein structure; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001099895,0.0007253987,0.0007181407,0.0006438527,0.000381401,0.0005752648,0.001767255,0.0007510681,0.00001574671],"category_scores_gemma":[0.0004121716,0.0008297447,0.0001433151,0.0009013609,0.00009259106,0.000392554,0.00241987,0.001400737,0.00005276335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005781307,"about_ca_system_score_gemma":0.001119651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002885311,"about_ca_topic_score_gemma":0.00001925869,"domain_scores_codex":[0.9954625,0.0003763885,0.0007462523,0.00198569,0.0006665859,0.0007625944],"domain_scores_gemma":[0.9954417,0.000184303,0.0005895944,0.002884988,0.0005216226,0.0003778118],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0002032715,0.0009418027,0.04075212,0.02334645,0.001363509,0.0007740161,0.0008146211,0.01076085,0.279041,0.6382938,0.002208501,0.001500053],"study_design_scores_gemma":[0.001674614,0.0002344058,0.3127214,0.00320136,0.0002435767,3.581511e-7,0.000005646991,0.6317424,0.04001027,0.00145045,0.005365873,0.00334961],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2488655,0.002839466,0.7314278,0.004980496,0.005868397,0.002587816,0.0002489731,0.003095309,0.000086265],"genre_scores_gemma":[0.9123186,0.0001211618,0.08667585,0.0004677491,0.0001302214,0.0001516888,0.00000100592,0.00007388127,0.00005979853],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.6634532,"threshold_uncertainty_score":0.9994153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01035595098640428,"score_gpt":0.2430984274611159,"score_spread":0.2327424764747117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}