{"id":"W4414694428","doi":"10.1101/2025.09.29.679218","title":"A mechanical origin for implantation defects in embryos from aged females","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of California, San Francisco; European Commission; Max-Planck-Gesellschaft; Echo Foundation","keywords":"Embryo; Contractility; Fertility; Implantation failure; Ageing; Reproductive technology; Embryo transfer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002429195,0.0002589878,0.000211518,0.0004639852,0.0001982067,0.0002139283,0.0001456249,0.0003052037,0.002662251],"category_scores_gemma":[0.0002732745,0.0001763307,0.000244136,0.0001245419,0.0002545177,0.0001628788,0.0003162557,0.000481985,0.0004674298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001188034,"about_ca_system_score_gemma":0.0001476864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003827014,"about_ca_topic_score_gemma":0.0004937078,"domain_scores_codex":[0.9999064,0.000008918945,0.000009420751,0.00002860733,0.0000303833,0.00001622193],"domain_scores_gemma":[0.9997547,0.00003578386,0.00009964848,0.0000343359,0.00002130513,0.00005420502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001461497,0.00001822223,0.01106071,0.00004460661,0.00001739747,0.0005899984,0.0000692726,0.00005470708,0.9824539,0.0002559592,0.0001691284,0.005119846],"study_design_scores_gemma":[0.00002795157,0.0005020389,0.5818146,0.00005313739,0.00008747367,0.01188947,0.0001844806,0.0007197988,0.3961742,0.0005819242,0.007939518,0.00002541936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985041,0.005131605,0.00522112,0.0003191021,0.00009583622,0.00002919689,0.001044363,0.0000950925,0.003022718],"genre_scores_gemma":[0.9909785,0.001545731,0.002343112,0.0002047231,0.00004897957,0.00003244572,0.000827931,0.00003666386,0.003981853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002662251,"threshold_uncertainty_score":0.008906066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03565199378640805,"score_gpt":0.2887728225406948,"score_spread":0.2531208287542868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}