{"id":"W4414700667","doi":"10.2139/ssrn.5457033","title":"Relative efficacy, safety, and immunogenicity analysis of two doses versus one dose of recombinant coronavirus vaccine (adenovirus type 5 vector) in adults 18 years and older: an international, multicentre, randomised, double blinded phase 3 trial","year":2025,"lang":"en","type":"preprint","venue":"SSRN Electronic Journal","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"","keywords":"Immunogenicity; Adverse effect; Placebo; Antibody; Clinical endpoint; Antibody response; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004218922,0.002717663,0.005285619,0.0005993844,0.0005511448,0.001762886,0.001315128,0.003273083,0.005172062],"category_scores_gemma":[0.005316503,0.001056091,0.003878494,0.0005532844,0.002318995,0.002109962,0.0006206417,0.004007548,0.0009610279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00115013,"about_ca_system_score_gemma":0.001215779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008381499,"about_ca_topic_score_gemma":0.0007903516,"domain_scores_codex":[0.9974889,0.001512962,0.0001715304,0.0003860533,0.0001675569,0.0002729984],"domain_scores_gemma":[0.996879,0.001456814,0.0006232677,0.0002907449,0.0001988009,0.0005513587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9926473,0.002384044,0.0001251881,0.000209604,0.0005168036,0.000009088368,0.0000278371,0.000129328,0.0008547496,0.00003645527,0.00008635773,0.002973339],"study_design_scores_gemma":[0.868923,0.1285367,0.0007929035,0.00002910985,0.0006779031,0.00001520345,0.00002221548,0.0002873357,0.0003597311,0.0001520038,0.0001852986,0.00001867383],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900331,0.004178706,0.001152627,0.000389973,0.0006586848,0.002059194,0.0004631289,0.00007683005,0.0009878821],"genre_scores_gemma":[0.9899669,0.001750158,0.001507381,0.0006762878,0.0005348806,0.003175587,0.0004811376,0.00003280943,0.001874838],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005285619,"threshold_uncertainty_score":0.02231205,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03838450260705448,"score_gpt":0.3832117938255787,"score_spread":0.3448272912185243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}