{"id":"W4414703035","doi":"10.3390/pathophysiology32040052","title":"Embryonic Signaling Pathways Shape Colorectal Cancer Subtypes: Linking Gut Development to Tumor Biology","year":2025,"lang":"en","type":"article","venue":"Pathophysiology","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Hindgut; Mesoderm; Colorectal cancer; Crosstalk; Embryonic stem cell; Morphogenesis; Endoderm; Brachyury; Transcriptome; Signal transduction; Mesenchyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002313405,0.0002749431,0.0002950668,0.0005805459,0.0001635438,0.0007261584,0.0001875042,0.0003328488,0.001438472],"category_scores_gemma":[0.0004091396,0.0001280564,0.0003197326,0.0005423739,0.0003007993,0.0005365706,0.0003222358,0.0005856348,0.000427732],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004167242,"about_ca_system_score_gemma":0.0004199666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001132002,"about_ca_topic_score_gemma":0.001809711,"domain_scores_codex":[0.9998432,0.00003075412,0.00001601797,0.0000395041,0.00004518653,0.00002532456],"domain_scores_gemma":[0.9998679,0.00003560347,0.00003353983,0.000005397718,0.00004224833,0.00001541355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007021225,0.00005364804,0.04558524,0.01025606,0.0004446873,0.003635668,0.001055179,0.002431373,0.2682866,0.01967344,0.0151502,0.6327257],"study_design_scores_gemma":[0.00004313792,0.0005698406,0.2613931,0.002907211,0.0009885428,0.01288019,0.001608495,0.002429982,0.06046409,0.01194823,0.6446318,0.0001352853],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.09913936,0.879407,0.005628692,0.002905587,0.0003489035,0.00003367587,0.000976083,0.0001694114,0.01139133],"genre_scores_gemma":[0.2586811,0.7315811,0.003467632,0.0007903298,0.0002473052,0.00002814737,0.0009841358,0.00003326768,0.004186913],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001438472,"threshold_uncertainty_score":0.004812181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0306735709124022,"score_gpt":0.3421091316501554,"score_spread":0.3114355607377532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}