{"id":"W4414704521","doi":"10.3390/foods14193404","title":"Inhibition of Xanthine Oxidase by Four Phenolic Acids: Kinetic, Spectroscopic, Molecular Simulation, and Cellular Insights","year":2025,"lang":"en","type":"article","venue":"Foods","topic":"Gout, Hyperuricemia, Uric Acid","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Shanghai Jiao Tong University; National Natural Science Foundation of China","keywords":"Xanthine oxidase; Protocatechuic acid; Gallic acid; Phenolic acid; Uric acid; Hydrophobic effect; Oxidase test; Phenols","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001156177,0.0002708758,0.0002502521,0.00008435983,0.0001255204,0.0002367921,0.0002009833,0.000195068,0.0004697456],"category_scores_gemma":[0.0001607252,0.00009117583,0.0003232096,0.0001447878,0.000123088,0.0002070351,0.0001091111,0.0002771938,0.00007680888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002865064,"about_ca_system_score_gemma":0.0001814299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001741292,"about_ca_topic_score_gemma":0.001658425,"domain_scores_codex":[0.9999567,0.000007319156,0.000002656646,0.00001003433,0.00001317894,0.0000100778],"domain_scores_gemma":[0.9999452,0.00001672613,0.00001639058,0.000003620081,0.0000107242,0.000007270554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004933415,0.0002328132,0.00393172,0.0003823889,0.0001097938,0.0001551342,0.00008693623,0.03367461,0.9480084,0.001352446,0.0002453601,0.01132705],"study_design_scores_gemma":[0.00004974097,0.0008143567,0.005830144,0.0000128384,0.00009622751,0.0001067757,0.00007506459,0.242442,0.7476006,0.0003354647,0.002608118,0.00002866579],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947689,0.001091524,0.003063027,0.00005208823,0.00001399246,0.000008756941,0.0001167201,0.00003700759,0.0008480257],"genre_scores_gemma":[0.9968622,0.0008053902,0.001821574,0.00001102626,0.000002638957,0.00001181985,0.00009772966,0.000005564383,0.0003822139],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001741292,"threshold_uncertainty_score":0.003462315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009550410612517811,"score_gpt":0.261344095323619,"score_spread":0.2517936847111011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}