{"id":"W4414710139","doi":"10.1016/j.esmoop.2025.105597","title":"19MO Desaminotyrosine is a key driver of the success of immunotherapy with fecal microbial transplantation in cancer","year":2025,"lang":"en","type":"article","venue":"ESMO Open","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; London Health Sciences Centre","funders":"","keywords":"Immunotherapy; Cancer; Fecal bacteriotherapy; Transplantation; Key (lock); Cancer immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001340999,0.00009103977,0.0002493019,0.00006983917,0.0000310405,0.00001153767,0.0002540951,0.00005556393,0.0003327977],"category_scores_gemma":[0.000002152552,0.00005678765,0.00006134038,0.0004002189,0.0001471551,0.00007399257,0.00002392096,0.00008717894,3.706599e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006974082,"about_ca_system_score_gemma":0.0002953871,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02940781,"about_ca_topic_score_gemma":0.008272588,"domain_scores_codex":[0.9993595,0.00003999944,0.0002435732,0.0001373844,0.0001161776,0.0001033951],"domain_scores_gemma":[0.9995944,0.0000257543,0.00009899047,0.000212446,0.00005748404,0.00001086726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02740349,0.0004410343,0.5494658,0.0003924588,0.0005232632,0.000008362146,0.005993784,0.00002138725,0.3875099,0.0001424103,0.001693446,0.02640467],"study_design_scores_gemma":[0.006373443,0.0001181649,0.6289694,0.001005185,0.00005371693,0.000004462485,0.0000500451,0.000009755485,0.3609392,0.0000110259,0.002410857,0.00005470535],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950184,0.0005117477,0.00007334929,0.002263821,0.0001146106,0.000735803,0.00004572355,0.00000360476,0.00123292],"genre_scores_gemma":[0.9966676,0.0007453194,0.0002080439,0.001088468,0.00001101197,0.0000349842,0.00000947203,0.000009037351,0.001226103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07950358,"threshold_uncertainty_score":0.9770554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01319207423595532,"score_gpt":0.3068517226223231,"score_spread":0.2936596483863678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}