{"id":"W4414710167","doi":"10.1016/j.esmoop.2025.105651","title":"76eP Clinical-grade comprehensive genomic profiling (CGP) of urothelial carcinoma (UC)","year":2025,"lang":"en","type":"article","venue":"ESMO Open","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Calgary Laboratory Services; Occupational Cancer Research Centre; University of Calgary","funders":"","keywords":"Urothelial carcinoma; Profiling (computer programming); Urothelial cancer; Gene expression profiling; Bladder cancer; Genomic sequencing","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004049682,0.0003332588,0.0003579582,0.001000268,0.0003346392,0.0009259128,0.0002351284,0.0005131437,0.005449536],"category_scores_gemma":[0.0009172492,0.0001466591,0.000290431,0.0009554288,0.0001916974,0.0002887418,0.000500682,0.0004618081,0.001115228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004471837,"about_ca_system_score_gemma":0.0005405312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002218539,"about_ca_topic_score_gemma":0.006878544,"domain_scores_codex":[0.9996137,0.00006511524,0.00003612614,0.00009945946,0.0001185377,0.00006711164],"domain_scores_gemma":[0.9996898,0.00005496843,0.00006502964,0.0000433933,0.00009552642,0.00005124383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.00173205,0.0002035898,0.3080736,0.001070815,0.000480242,0.001162533,0.0002135649,0.003006529,0.2043576,0.002269633,0.02982471,0.4476052],"study_design_scores_gemma":[0.0001347505,0.0008876433,0.7473962,0.0003256025,0.000758052,0.005227874,0.000502652,0.004181621,0.1172213,0.004179412,0.1191345,0.00005033058],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8453366,0.03149012,0.02021546,0.005020116,0.0006051091,0.0005871195,0.03972329,0.0009930213,0.05602914],"genre_scores_gemma":[0.9542984,0.00542314,0.01256255,0.001685793,0.0001557875,0.0002471661,0.01500105,0.0001126977,0.01051343],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005449536,"threshold_uncertainty_score":0.0182305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08534673143963108,"score_gpt":0.4059433389521601,"score_spread":0.3205966075125291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}