{"id":"W4414713795","doi":"10.1016/j.jclinane.2025.112014","title":"Safety and feasibility of intraoperative high PEEP titrated to the lowest driving pressure during anesthesia for minimally invasive abdominal surgery – Interim analysis of GENERATOR","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Anesthesia","topic":"Hemodynamic Monitoring and Therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"ZonMw","keywords":"Interim analysis; Abdominal surgery; Invasive surgery; Interim; Generator (circuit theory)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01208063,0.001230373,0.002702471,0.0004306823,0.0003641783,0.001185136,0.00075513,0.001545324,0.003835235],"category_scores_gemma":[0.01155316,0.0005352507,0.006018322,0.0003921025,0.0007381675,0.001063736,0.0005260903,0.002319907,0.0007016232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006096796,"about_ca_system_score_gemma":0.001442484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001667372,"about_ca_topic_score_gemma":0.0002441474,"domain_scores_codex":[0.9926945,0.004912474,0.0004593614,0.000557423,0.0005922786,0.0007839308],"domain_scores_gemma":[0.9905033,0.004399067,0.002584483,0.0015154,0.0005067682,0.0004909824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9554056,0.005379609,0.008174689,0.0005335276,0.003453667,0.00008901647,0.00005782091,0.00202031,0.002834111,0.0002117849,0.001875422,0.01996446],"study_design_scores_gemma":[0.3412629,0.5396392,0.08368314,0.0002010183,0.01022642,0.0002091654,0.00008304669,0.006524635,0.01236275,0.001895228,0.003771883,0.0001405209],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849237,0.001138124,0.003083871,0.0005530353,0.0003235433,0.003667693,0.003402552,0.0001200296,0.00278742],"genre_scores_gemma":[0.983279,0.0002997692,0.00378366,0.0006646853,0.000208019,0.00823598,0.002321329,0.00003608608,0.001171486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01208063,"threshold_uncertainty_score":0.06388921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04189970614248532,"score_gpt":0.3739266938899243,"score_spread":0.3320269877474389,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}