{"id":"W4414714422","doi":"10.1016/j.cjca.2025.08.053","title":"P051 MESENCHYMAL STROMAL CELL DERIVED MRNA THERAPY FOR FONTAN-ASSOCIATED LIVER DISEASE: PRECLINICAL DESIGN, VALIDATION AND PRELIMINARY RESULTS","year":2025,"lang":"en","type":"article","venue":"Canadian Journal of Cardiology","topic":"Transplantation: Methods and Outcomes","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Public Health","funders":"","keywords":"Mesenchymal stem cell; Stromal cell; Pathological; Fibrosis; Cell; Disease; Liver fibrosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001206428,0.0004824582,0.0004837446,0.0003331654,0.0003013969,0.0007383185,0.0002971026,0.0003704103,0.003345596],"category_scores_gemma":[0.0004404131,0.00009892409,0.0004496209,0.0002350861,0.0006331025,0.0003319916,0.0001686507,0.001241931,0.000648228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003648938,"about_ca_system_score_gemma":0.0008754093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005415249,"about_ca_topic_score_gemma":0.001073601,"domain_scores_codex":[0.9995531,0.0001269462,0.00002593854,0.00006030562,0.0001482912,0.00008525798],"domain_scores_gemma":[0.9997481,0.00007411322,0.00004065747,0.00002791098,0.00004355641,0.00006580806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004711829,0.006944664,0.0010344,0.0006941271,0.00009343533,0.0001937405,0.0001930337,0.001903045,0.9191241,0.001395498,0.001543648,0.0621684],"study_design_scores_gemma":[0.001326306,0.1176589,0.007222373,0.00009861444,0.000419439,0.0004146062,0.000220776,0.005154332,0.8491747,0.0004439781,0.01783489,0.00003113517],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9714797,0.00311215,0.01609072,0.0005034397,0.0004158653,0.00124157,0.0009371085,0.0002326648,0.005986802],"genre_scores_gemma":[0.9737276,0.004116142,0.01471558,0.0002867408,0.0001484078,0.0009894769,0.00177101,0.00005930258,0.004185638],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003345596,"threshold_uncertainty_score":0.0111922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05825674910268071,"score_gpt":0.336443081414973,"score_spread":0.2781863323122923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}