{"id":"W4414714424","doi":"10.1016/j.cjca.2025.08.201","title":"P361 MULTI-ANCESTRY PROTEOME-WIDE MENDELIAN RANDOMIZATION IDENTIFIES RISK PROTEINS FOR INTRACRANIAL ANEURYSMS","year":2025,"lang":"en","type":"article","venue":"Canadian Journal of Cardiology","topic":"Intracranial Aneurysms: Treatment and Complications","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Mendelian randomization; Randomization; MEDLINE; Aneurysm; Mendelian inheritance; Risk assessment","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001814345,0.001070262,0.0007353503,0.001137344,0.0009481627,0.001007096,0.0007807799,0.001308302,0.004582],"category_scores_gemma":[0.004615372,0.0003909693,0.001940918,0.001351855,0.0005597805,0.00045204,0.0008384475,0.001196648,0.0003794902],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002712182,"about_ca_system_score_gemma":0.0003861628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003405576,"about_ca_topic_score_gemma":0.002149587,"domain_scores_codex":[0.9975974,0.0009626605,0.0001486353,0.0008282966,0.0002430032,0.0002199841],"domain_scores_gemma":[0.9982888,0.0007848992,0.0004536221,0.0002461759,0.00008339438,0.0001430352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0268471,0.0004074186,0.7796045,0.0003867335,0.01167084,0.01744483,0.001367946,0.003818186,0.09504047,0.007824049,0.007659134,0.04792891],"study_design_scores_gemma":[0.0008680784,0.001022214,0.9450446,0.00008620209,0.005057171,0.0149569,0.0003930961,0.01470391,0.00620445,0.006186371,0.005360818,0.0001162329],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910171,0.0004543825,0.005528281,0.0005210412,0.000105712,0.00002977415,0.001266676,0.0001282154,0.0009487591],"genre_scores_gemma":[0.9966484,0.0001252235,0.00209879,0.0001176062,0.00004823678,0.00002043873,0.0004234359,0.00006351741,0.0004544925],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004582,"threshold_uncertainty_score":0.01532829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02034194096755017,"score_gpt":0.2744902524840918,"score_spread":0.2541483115165416,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}