{"id":"W4414727088","doi":"10.1093/jnci/djaf272","title":"Stratifying lung adenocarcinoma risk with multi-ancestry polygenic risk scores in East Asian never-smokers","year":2025,"lang":"en","type":"article","venue":"JNCI Journal of the National Cancer Institute","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Princess Margaret Cancer Centre; Sinai Health System; Lunenfeld-Tanenbaum Research Institute","funders":"Program for Changjiang Scholars and Innovative Research Team in University; National Cancer Institute; University of Colorado Denver; State Key Laboratory of Computer Science; National Key Research and Development Program of China; National Science Council; Ministry of Health; Natural Science Foundation of Guangdong Province; National Health Research Institutes; National Research Foundation of Korea; Agency for Science, Technology and Research; Georgetown University; Marshfield Clinic Research Foundation; McDonnell Center for Systems Neuroscience; Ministry of Education, Culture, Sports, Science and Technology; National Cancer Center; Ministry of Science and Technology; National Natural Science Foundation of China; National Foundation for Cancer Research; University of Pittsburgh; Henry Ford Health System; Washington University in St. Louis; National Institutes of Health; University of California; University of Alabama at Birmingham; National Medical Research Council; University of Utah; World Health Organization; University of Minnesota; China Medical Board","keywords":"Polygenic risk score; Risk stratification; East Asia; Adenocarcinoma; Risk assessment; Lung","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005508911,0.0007315825,0.0005041728,0.001459491,0.000386692,0.001094172,0.000511606,0.0005127227,0.0009523251],"category_scores_gemma":[0.007399903,0.0002698278,0.001213143,0.0008183632,0.0002814399,0.0004952212,0.0009944713,0.0007298086,0.000291249],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003730765,"about_ca_system_score_gemma":0.0004528254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007363302,"about_ca_topic_score_gemma":0.01160107,"domain_scores_codex":[0.9989918,0.0004959884,0.00008774031,0.0002667908,0.00009158218,0.00006605816],"domain_scores_gemma":[0.9965444,0.001399227,0.0007087091,0.0005730267,0.0004341023,0.0003405497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002602824,0.00001735626,0.9915482,0.00001202997,0.0002549017,0.00002715228,0.0000466118,0.001570247,0.0002079547,0.00004161398,0.0001376801,0.005875899],"study_design_scores_gemma":[0.00003731525,0.0002364216,0.9355022,0.00004382502,0.0007160635,0.0002650972,0.0001586863,0.0610148,0.0007789299,0.0006467923,0.0005725903,0.00002733205],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960428,0.0003557286,0.002625754,0.00009375811,0.000009024979,0.00001502214,0.0004887491,0.00004015551,0.0003289825],"genre_scores_gemma":[0.9976636,0.00009114191,0.001528202,0.00002106081,0.000009868865,0.000006611195,0.0005673816,0.000007851863,0.0001043371],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007363302,"threshold_uncertainty_score":0.02913427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03379504628907702,"score_gpt":0.3312543379563414,"score_spread":0.2974592916672644,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}