{"id":"W4414733273","doi":"10.26434/chemrxiv-2025-j5dmz","title":"On-resin Pictet-Spengler Cyclisation for 1,2,3,4-Tetrahydro-β-carboline-3-carboxylate (Tcc) Peptide Synthesis with Acid Labile Functional Tolerance","year":2025,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Synthesis and bioactivity of alkaloids","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Linker; Peptide; Tryptophan; Peptide synthesis; Amino acid; Side chain","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002805809,0.0006451891,0.0003216542,0.0002652877,0.0002012055,0.0002472668,0.0003076448,0.0004977453,0.005863684],"category_scores_gemma":[0.0003177423,0.0001955604,0.0003911345,0.000249043,0.0002624815,0.0003309459,0.0003670478,0.0009902107,0.002410248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003506114,"about_ca_system_score_gemma":0.0002738271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003954176,"about_ca_topic_score_gemma":0.000775483,"domain_scores_codex":[0.9997907,0.00003645442,0.00001188992,0.00005450904,0.00005983371,0.00004654564],"domain_scores_gemma":[0.9998304,0.00002916395,0.0000422515,0.00004372452,0.00001824885,0.00003625595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008824882,0.00003370858,0.00003515841,0.0001415246,0.00001161533,0.0001411268,0.00004228656,0.0002334819,0.9937671,0.0004121026,0.0003607517,0.004732865],"study_design_scores_gemma":[0.00001918759,0.0002474146,0.0006430281,0.000008545565,0.00001091553,0.0004148991,0.00000825937,0.0004637558,0.9861233,0.00008872802,0.01195464,0.00001728691],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8443321,0.003949865,0.1159068,0.0004657668,0.0003568991,0.0007588725,0.002477406,0.00226345,0.02948874],"genre_scores_gemma":[0.9021378,0.00256835,0.06384245,0.000284713,0.00007827912,0.0003295511,0.002881882,0.0006067017,0.02727041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005863684,"threshold_uncertainty_score":0.01961601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01721811802471837,"score_gpt":0.2415920734461838,"score_spread":0.2243739554214655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}