{"id":"W4414737738","doi":"10.1101/2025.09.30.679035","title":"Splenic granulopoiesis and S100A9 drive resistance to checkpoint inhibitors conferred by liver metastases","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Wellcome Trust","keywords":"Granulopoiesis; S100A9; Spleen; Immune system; Metastasis; Tumor microenvironment; Blockade","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008119395,0.0001849513,0.000161024,0.0001082372,0.00006587156,0.0002037684,0.0001066012,0.0002151446,0.001756677],"category_scores_gemma":[0.00008259303,0.00008230026,0.0001193302,0.00005222367,0.0001960686,0.00009732817,0.0001674427,0.0005856474,0.0003119397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002025774,"about_ca_system_score_gemma":0.0001258707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003688898,"about_ca_topic_score_gemma":0.0005585348,"domain_scores_codex":[0.9999419,0.00001109277,0.000003259938,0.000009171637,0.00001782724,0.00001665829],"domain_scores_gemma":[0.9999365,0.00001004399,0.00002021317,0.000008467637,0.000004154141,0.00002059644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001843036,0.0000467102,0.0003776385,0.00001524791,0.000002675621,0.00003960162,0.00000686118,0.00007851628,0.9975237,0.0001286329,0.00006847064,0.001527505],"study_design_scores_gemma":[0.00005252726,0.0006642588,0.007720253,0.00000511026,0.000009237985,0.0003295693,0.00003268043,0.001461984,0.9875904,0.0001188703,0.00201278,0.000002349723],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967603,0.0005956373,0.001069709,0.0001402644,0.00001469739,0.00002033746,0.0001569657,0.00007198323,0.001170105],"genre_scores_gemma":[0.9977181,0.0002122345,0.0004832341,0.0000355695,0.000003568824,0.00001363312,0.0001259775,0.00001120727,0.001396508],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001756677,"threshold_uncertainty_score":0.00587666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008085911793779987,"score_gpt":0.215318765042117,"score_spread":0.207232853248337,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}