{"id":"W4414740921","doi":"10.1093/clinchem/hvaf086.512","title":"B-115 Development of Anti-14-3-3eta Multiplex Laboratory Developed Test (LDT) to aid in the Diagnosis of Axial Spondyloarthritis (axSpA)","year":2025,"lang":"en","type":"article","venue":"Clinical Chemistry","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of British Columbia; Kinexus Bioinformatics Corporation (Canada)","funders":"","keywords":"Youden's J statistic; Multiplex; Axial spondyloarthritis; Receiver operating characteristic; Autoantibody; Diagnostic accuracy; Ranging","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006021501,0.0009310702,0.0005756675,0.002786887,0.0003090706,0.001521559,0.0006310633,0.001180766,0.0015445],"category_scores_gemma":[0.005670717,0.000483825,0.0006243718,0.0008718906,0.0004682335,0.00036795,0.0006270293,0.0007861494,0.001254537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005589403,"about_ca_system_score_gemma":0.0004991966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008548892,"about_ca_topic_score_gemma":0.0009786466,"domain_scores_codex":[0.9947628,0.00209184,0.0003755665,0.0008359515,0.001732314,0.0002014952],"domain_scores_gemma":[0.9967878,0.001118572,0.0006083675,0.0002433754,0.001005512,0.0002363748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002650399,0.0008865352,0.2768676,0.0008509715,0.0004479782,0.0009031804,0.0003928023,0.004092834,0.5348696,0.0007800714,0.003519874,0.1737383],"study_design_scores_gemma":[0.0004030016,0.008217097,0.2611668,0.0005541827,0.0005604212,0.01028027,0.0002676798,0.1127701,0.586111,0.001182355,0.0183052,0.0001819278],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8137775,0.009631886,0.1583215,0.0007495185,0.0005460149,0.001033044,0.003256732,0.003819405,0.008864424],"genre_scores_gemma":[0.8962038,0.0007331414,0.09845984,0.0005903509,0.00006926493,0.0003985703,0.001318231,0.00007144286,0.002155568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006021501,"threshold_uncertainty_score":0.03184509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04304002818581731,"score_gpt":0.3597655157827565,"score_spread":0.3167254875969392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}