{"id":"W4414741342","doi":"10.1093/clinchem/hvaf086.574","title":"B-181 Second-tier newborn screening for X-linked adrenoleukodystrophy: development, validation, and clinical application of an LC-MS/ MS method for the quantification of lysophosphatidylcholines","year":2025,"lang":"en","type":"article","venue":"Clinical Chemistry","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Newborn Screening Ontario; Children's Hospital of Eastern Ontario; McMaster University","funders":"","keywords":"Newborn screening; Adrenoleukodystrophy; Tandem mass spectrometry; Analyte; Electrospray ionization; Mass spectrometry; High-performance liquid chromatography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001611383,0.0001859096,0.0003990343,0.00002327031,0.0001208169,0.00001966838,0.0003537709,0.0004948812,0.00000945622],"category_scores_gemma":[0.001532946,0.0001571653,0.0002083089,0.0001359446,0.0002435896,0.00001157341,0.00009592808,0.0001711909,2.725059e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001063668,"about_ca_system_score_gemma":0.0002521262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004670827,"about_ca_topic_score_gemma":0.000004904852,"domain_scores_codex":[0.9977185,0.00009886373,0.00130234,0.0005996806,0.0001025001,0.0001781559],"domain_scores_gemma":[0.9975256,0.0006708736,0.0006324018,0.0005638447,0.0005176821,0.00008963575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008856846,0.000314634,0.03151269,0.0003368649,0.0004623489,2.659245e-8,0.00001501541,0.00006454036,0.8192852,0.00004636837,0.0005233502,0.1465533],"study_design_scores_gemma":[0.001527523,0.0001122709,0.005942223,0.00003120997,0.0001241811,6.210962e-7,0.00005491157,0.003477804,0.9547133,0.0001141195,0.03375065,0.0001512193],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5792512,0.0002868075,0.4196551,0.0001213212,0.00009776929,0.0004882425,0.00006106011,0.0000105203,0.00002790656],"genre_scores_gemma":[0.8170652,0.0001323029,0.1806937,0.0001337892,0.0003894992,0.0002705812,0.0009555974,0.00003022213,0.0003291218],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2389614,"threshold_uncertainty_score":0.6409014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04347689666606077,"score_gpt":0.3939698368414656,"score_spread":0.3504929401754048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}