{"id":"W4414741342","doi":"10.1093/clinchem/hvaf086.574","title":"B-181 Second-tier newborn screening for X-linked adrenoleukodystrophy: development, validation, and clinical application of an LC-MS/ MS method for the quantification of lysophosphatidylcholines","year":2025,"lang":"en","type":"article","venue":"Clinical Chemistry","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Newborn Screening Ontario; Children's Hospital of Eastern Ontario; McMaster University","funders":"","keywords":"Newborn screening; Adrenoleukodystrophy; Tandem mass spectrometry; Analyte; Electrospray ionization; Mass spectrometry; High-performance liquid chromatography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001898855,0.001096479,0.0004683271,0.001714205,0.0008240722,0.0009373977,0.0008225458,0.001210445,0.001562198],"category_scores_gemma":[0.002085662,0.0004330393,0.0003135387,0.0006082869,0.001047209,0.0002743192,0.0006704691,0.0007900595,0.001262738],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00193801,"about_ca_system_score_gemma":0.003827461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0444187,"about_ca_topic_score_gemma":0.06310476,"domain_scores_codex":[0.997957,0.0002691073,0.0001230213,0.0002935593,0.001216866,0.0001404242],"domain_scores_gemma":[0.9989527,0.0001373184,0.0001187739,0.00005749087,0.0005847673,0.0001488672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001116565,0.0002220898,0.03240915,0.0003356574,0.0001154248,0.000844017,0.00026492,0.0005213483,0.9181167,0.0002552682,0.001663199,0.04413569],"study_design_scores_gemma":[0.0001945747,0.002792356,0.1310012,0.0001768969,0.0002140985,0.008464737,0.0004002035,0.009128285,0.8287615,0.0002464296,0.01848041,0.0001394162],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.857292,0.01300206,0.1028988,0.001882214,0.0002698861,0.003442574,0.006238692,0.003491695,0.01148207],"genre_scores_gemma":[0.8594924,0.003890088,0.118985,0.001822156,0.00006553499,0.0009573413,0.003479223,0.0002024971,0.01110578],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.0444187,"threshold_uncertainty_score":0.08832031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04347689666606077,"score_gpt":0.3939698368414656,"score_spread":0.3504929401754048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}