{"id":"W4414747400","doi":"10.1038/s41467-025-63865-6","title":"Pathogenic variants reveal candidate genes for prostate cancer germline testing for men of African ancestry","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"Congressionally Directed Medical Research Programs; National Institute of Environmental Health Sciences; National Cancer Institute; Medical Research Council; University of New South Wales; National Institute for Health and Care Research; DOD Prostate Cancer Research Program; Royal Marsden NHS Foundation Trust; U.S. Department of Health and Human Services; National Institutes of Health; Prostate Cancer UK; National Health and Medical Research Council; Cancer Research UK; Movember Foundation; Prostate Cancer Foundation; Petre Foundation; U.S. Department of Defense","keywords":"MSH6; Germline; Candidate gene; Gene; Prostate cancer; DNA sequencing; DNA mismatch repair; Genome; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005011198,0.0003457649,0.0002260903,0.001069029,0.0004212339,0.0006792014,0.0002616791,0.0004083947,0.004824357],"category_scores_gemma":[0.002092058,0.0001394687,0.0003462624,0.0008495051,0.000334711,0.0002518184,0.0004208776,0.0003955301,0.0004428954],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001245141,"about_ca_system_score_gemma":0.0002081338,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001236071,"about_ca_topic_score_gemma":0.001979824,"domain_scores_codex":[0.9997147,0.00006172516,0.00001886778,0.00008224604,0.00006437576,0.00005819272],"domain_scores_gemma":[0.9994783,0.0002021248,0.0001766737,0.00004200052,0.0000360376,0.00006499822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005808535,0.00003589135,0.8865018,0.0001186755,0.0001727699,0.003664242,0.000484917,0.0007027558,0.02688007,0.001208982,0.001877779,0.07777122],"study_design_scores_gemma":[0.00003455794,0.0002265752,0.9617189,0.000135768,0.0003196723,0.01567431,0.000793642,0.002719266,0.008231662,0.003287836,0.006824438,0.00003331697],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919694,0.002897888,0.00178452,0.0005696376,0.00003255221,0.00001152152,0.0006785907,0.00007260752,0.001983333],"genre_scores_gemma":[0.9980676,0.0005704783,0.0008090192,0.00007045061,0.00002977907,0.000001939084,0.0002156091,0.00001029915,0.0002248472],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004824357,"threshold_uncertainty_score":0.01613915,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06459854155016023,"score_gpt":0.4134262524255371,"score_spread":0.3488277108753769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}