{"id":"W4414750828","doi":"10.3390/biom15101406","title":"NEK Family Kinases: Structure, Function, and Role in Disease","year":2025,"lang":"en","type":"review","venue":"Biomolecules","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; Janssen Biotech; National Cancer Institute; National Institutes of Health; National Institute of General Medical Sciences; Ontario Genomics Institute; Merck KGaA; Genentech; Bayer; Pfizer; Bristol-Myers Squibb","keywords":"Disease; Function (biology); Variety (cybernetics); Mechanism (biology); Kinase","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00007617287,0.0003729979,0.0005209605,0.0001697946,0.00005442996,0.00004913637,0.0002102262,0.0003182598,0.00001272663],"category_scores_gemma":[0.00009538613,0.0003266059,0.0001870717,0.0002121586,0.0001095971,0.000002440372,0.0002114418,0.0001356532,0.000006723601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001634618,"about_ca_system_score_gemma":0.0003684156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002686558,"about_ca_topic_score_gemma":0.00003172526,"domain_scores_codex":[0.9985729,0.0001544224,0.0003126305,0.0006058414,0.00009946022,0.0002546866],"domain_scores_gemma":[0.9992983,0.00001971326,0.0001088394,0.000405552,0.00003362513,0.000133986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007248249,0.00007056753,0.0001048185,0.0118945,0.0001341478,0.00003264986,0.000009928252,4.785956e-7,0.004303964,0.0008622623,0.001041211,0.981473],"study_design_scores_gemma":[0.0002195094,0.00007698892,0.0001354388,0.002381805,0.000197267,0.000005838272,0.00001507349,0.000001237944,0.0003172444,0.0005469142,0.9957319,0.0003708023],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005267008,0.9975396,0.0001234472,0.00001094817,0.0001529418,0.0005572663,0.0005259936,0.0000163626,0.0005467555],"genre_scores_gemma":[0.001145119,0.996736,0.0001153307,0.0001788658,0.0001635794,0.000115681,0.001196128,0.00003599362,0.0003133203],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9946907,"threshold_uncertainty_score":0.9999186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01394748478004072,"score_gpt":0.2765221872180681,"score_spread":0.2625747024380274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}