{"id":"W4414751930","doi":"10.1016/j.ymthe.2025.09.047","title":"BiTE-secreting T cells rationally combine with PD-1 blockade and vaccine boosting to reshape antitumor immunity in ovarian cancer","year":2025,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; McMaster University Medical Centre","funders":"National Cancer Institute; Ovarian Cancer Research Alliance; U.S. Department of Defense; Ovarian Cancer Research Fund Alliance; Roswell Park Alliance Foundation, Roswell Park Cancer Institute; Roswell Park Cancer Institute","keywords":"Ovarian cancer; Immune system; Blockade; T cell; Myeloid-derived Suppressor Cell; Boosting (machine learning); Epitope; Cytotoxic T cell; Tumor microenvironment; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001328494,0.0002751482,0.0002961098,0.0002086802,0.0001340101,0.0004598566,0.0001932159,0.0003892052,0.001655201],"category_scores_gemma":[0.0001648341,0.0001460088,0.0002323022,0.0001474232,0.0002230522,0.0003311766,0.0003075659,0.001398919,0.0004173059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001778536,"about_ca_system_score_gemma":0.0002793278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001868185,"about_ca_topic_score_gemma":0.0004264033,"domain_scores_codex":[0.9998989,0.00001401772,0.000004790541,0.00001697183,0.00001889335,0.00004641418],"domain_scores_gemma":[0.9999683,0.000006994413,0.000007288551,0.000004907481,0.000003070496,0.000009456926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001719051,0.001561833,0.001314456,0.000258269,0.00006325339,0.0001870124,0.00009397408,0.005815512,0.8851891,0.002496,0.002122204,0.09917937],"study_design_scores_gemma":[0.001165121,0.009820704,0.003631475,0.00004965723,0.0002427753,0.0008264843,0.0001817486,0.01677291,0.9389004,0.002486089,0.02588521,0.00003738806],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864264,0.003718054,0.004763386,0.0006393026,0.0002682717,0.0001292423,0.0001533901,0.0002151393,0.003686927],"genre_scores_gemma":[0.9953716,0.000978551,0.002093264,0.0001723749,0.00003163834,0.00005239879,0.00009939855,0.00001229989,0.00118836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001655201,"threshold_uncertainty_score":0.005537152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008522708736843989,"score_gpt":0.2740198302919888,"score_spread":0.2654971215551448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}