{"id":"W4414754283","doi":"10.1128/mbio.02052-25","title":"Microbiota-derived aromatic amino acid decarboxylases: linking microbial fitness and host neurochemical communication","year":2025,"lang":"en","type":"review","venue":"mBio","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovation Cluster (Canada)","funders":"LEO Fondet; Institut Teknologi Sepuluh Nopember; Deutsche Forschungsgemeinschaft","keywords":"Monoamine neurotransmitter; Aromatic amino acids; Gut flora; Host (biology); Neurochemical; Immune system; Innate immune system; Microbiome; Bacteria; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001093324,0.0005038246,0.001071107,0.0002187966,0.000252655,0.0002308576,0.0009812289,0.0003946053,0.00002423662],"category_scores_gemma":[0.0005400481,0.000468475,0.0002907421,0.000522821,0.0003745681,0.00009385173,0.0005969269,0.000610386,0.00006679324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006471508,"about_ca_system_score_gemma":0.0001846633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008291076,"about_ca_topic_score_gemma":0.000008102293,"domain_scores_codex":[0.9976917,0.0004372445,0.000586227,0.0007635248,0.0001404086,0.0003809287],"domain_scores_gemma":[0.9979013,0.0008328836,0.0003228617,0.0008338641,0.00001810514,0.00009104574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001635858,0.0002622909,0.000003366734,0.03050076,0.00005140245,0.00003413247,0.0004201018,7.166006e-8,0.5899472,0.00009930022,0.001482886,0.3771822],"study_design_scores_gemma":[0.001226838,0.00007207931,0.00003040613,0.04116119,0.000559394,0.0002562874,0.00005573542,0.00001477661,0.1182936,0.0001376395,0.8365923,0.001599805],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.009800675,0.9880483,0.00002798212,0.0001077796,0.0002998283,0.0009437574,0.00008672674,0.0001620172,0.0005230063],"genre_scores_gemma":[0.002605306,0.9959111,0.0002695747,0.0006029282,0.00005157964,0.00006606781,0.0001239104,0.000052831,0.0003167501],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8351094,"threshold_uncertainty_score":0.9997767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03289401828313423,"score_gpt":0.2923902447944647,"score_spread":0.2594962265113305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}