{"id":"W4414754283","doi":"10.1128/mbio.02052-25","title":"Microbiota-derived aromatic amino acid decarboxylases: linking microbial fitness and host neurochemical communication","year":2025,"lang":"en","type":"review","venue":"mBio","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovation Cluster (Canada)","funders":"LEO Fondet; Institut Teknologi Sepuluh Nopember; Deutsche Forschungsgemeinschaft","keywords":"Monoamine neurotransmitter; Aromatic amino acids; Gut flora; Host (biology); Neurochemical; Immune system; Innate immune system; Microbiome; Bacteria; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002489675,0.0003508595,0.0005183055,0.0004806453,0.0001337748,0.0009217322,0.0002394144,0.0004834567,0.001855358],"category_scores_gemma":[0.0003467808,0.00008691554,0.0002698983,0.000436649,0.0002343234,0.0004238427,0.000385331,0.0005652099,0.0004777692],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005288356,"about_ca_system_score_gemma":0.0005710527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009092963,"about_ca_topic_score_gemma":0.001230269,"domain_scores_codex":[0.9998474,0.00003606834,0.00001429576,0.00003211119,0.00004205058,0.00002797045],"domain_scores_gemma":[0.9999034,0.00002558169,0.00002369282,0.000003114313,0.0000315034,0.0000127114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005748679,0.00009073461,0.004345481,0.02375804,0.0004508554,0.001090563,0.0003132929,0.001495554,0.1554123,0.01584987,0.02231097,0.7743076],"study_design_scores_gemma":[0.00004161306,0.0005968336,0.01620252,0.003883021,0.0004528445,0.002768913,0.0004016714,0.001124058,0.04239493,0.007143453,0.9249308,0.00005935112],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.009784692,0.9834331,0.001850502,0.001116517,0.0004624931,0.00001290436,0.0001880442,0.0000297461,0.003121922],"genre_scores_gemma":[0.0870849,0.9064436,0.001528597,0.0006506332,0.0004994838,0.00002751799,0.000313442,0.000009637925,0.003442242],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001855358,"threshold_uncertainty_score":0.006206751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03289401828313423,"score_gpt":0.2923902447944647,"score_spread":0.2594962265113305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}