{"id":"W4414754323","doi":"10.1186/s11658-025-00785-9","title":"RSL3 promotes PARP1 apoptotic functions by distinct mechanisms during ferroptosis","year":2025,"lang":"en","type":"article","venue":"Cellular & Molecular Biology Letters","topic":"Ferroptosis and cancer prognosis","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Science and Technology Project of Zhejiang Province; Wenzhou Medical University; Science and Technology Plan Project of Wenzhou, China; University of South China; University of Alberta; Guangzhou Medical University","keywords":"Apoptosis; Crosstalk; PARP1; Programmed cell death; DNA damage; Cell cycle","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001719807,0.0003309806,0.0003760058,0.0002842493,0.0002266966,0.0003757431,0.0002267316,0.0003733223,0.001826091],"category_scores_gemma":[0.0001635592,0.0001594717,0.0005741239,0.000204207,0.0003360451,0.0002938675,0.0002281668,0.0009534091,0.0005681043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005533844,"about_ca_system_score_gemma":0.0002771729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004790225,"about_ca_topic_score_gemma":0.0008142235,"domain_scores_codex":[0.9997285,0.00004340214,0.00002840468,0.00005833093,0.00008094063,0.00006046358],"domain_scores_gemma":[0.999859,0.00001647626,0.00004341878,0.00001697407,0.00003289104,0.00003121485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003487368,0.00004130897,0.0002918984,0.00007956106,0.00001130497,0.00007921461,0.00003121131,0.00007667339,0.9972041,0.00009162768,0.0001418885,0.001602491],"study_design_scores_gemma":[0.00003692214,0.0002384668,0.004680258,0.000008438583,0.00001804181,0.0002609464,0.00005176003,0.0006048371,0.9913009,0.00008766087,0.002704762,0.000006964678],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849985,0.004285784,0.005552965,0.00045486,0.00006451663,0.0000840061,0.001381112,0.0003254442,0.002852866],"genre_scores_gemma":[0.9923632,0.001096619,0.002085083,0.0002217823,0.00001832769,0.0000867968,0.001189664,0.00003641506,0.002902141],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001826091,"threshold_uncertainty_score":0.00610882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005864479945234574,"score_gpt":0.2393254064089393,"score_spread":0.2334609264637048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}