{"id":"W4414756792","doi":"10.1021/acs.joc.5c01684","title":"Activation of <i>gem</i>-Dichloroacetamides and Epoxides Using Elemental Sulfur and Amines: A Route to Monothiooxalamides and α-Ketothioamides","year":2025,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Synthesis and Reactivity of Sulfur-Containing Compounds","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Drug Research and Development","funders":"National Science and Technology Council; National Tsing Hua University; Kaohsiung Medical University; Academia Sinica; National Sun Yat-sen University","keywords":"Regioselectivity; Epoxide; Amine gas treating; Sulfur; Ligand (biochemistry); Natural product; Chemical synthesis; Surface modification","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001126511,0.0003544303,0.0001057427,0.0001170954,0.00008263723,0.0001565186,0.0002539379,0.0001926901,0.00113416],"category_scores_gemma":[0.00008614215,0.0001463135,0.0001074753,0.00008225255,0.0001408315,0.0002221999,0.0001802204,0.0002940104,0.0004198966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001736684,"about_ca_system_score_gemma":0.0001354948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002604056,"about_ca_topic_score_gemma":0.0006948215,"domain_scores_codex":[0.9999318,0.000008759948,0.000005176179,0.00002016817,0.00001848834,0.00001561051],"domain_scores_gemma":[0.9999675,0.00000592948,0.00001140589,0.000004576627,0.000004752943,0.000005874948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000311294,0.000006206293,0.00004750734,0.0000330184,0.000002234351,0.0000546816,0.00001603121,0.00006042147,0.9979895,0.0001907202,0.00008491865,0.0014835],"study_design_scores_gemma":[0.000002926051,0.00003831309,0.0002115732,0.000001322738,0.000001377039,0.00007212983,0.000006785835,0.000252891,0.9979343,0.00002144777,0.001454836,0.00000200162],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9572177,0.001658229,0.02802754,0.0001753867,0.00005265779,0.00006486803,0.0004870562,0.0005776715,0.01173885],"genre_scores_gemma":[0.9829018,0.00107198,0.01104719,0.000049004,0.00001232761,0.00003126055,0.0003181632,0.00005167863,0.004516542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00113416,"threshold_uncertainty_score":0.003794134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01144576912561758,"score_gpt":0.2374789589141534,"score_spread":0.2260331897885358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}