{"id":"W4414776579","doi":"10.3390/ijms26199653","title":"Glutaminase Reprogramming in Hepatocellular Carcinoma: Implications for Diagnosis, Prognosis, and Potential as a Novel Therapeutic Target","year":2025,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Institut Du Cancer de Montréal","keywords":"Glutaminase; Glutaminolysis; Glutamine; Hepatocellular carcinoma; Glutamine synthetase; Metabolite; Reprogramming; Downregulation and upregulation; Metabolism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002935256,0.0003354107,0.0004874994,0.0003225367,0.00009855988,0.0005639042,0.0001863588,0.0003301518,0.0006044218],"category_scores_gemma":[0.0001877956,0.00009382505,0.0002681592,0.0003329821,0.0002516358,0.0003698979,0.0002542344,0.0006010918,0.000206942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005374905,"about_ca_system_score_gemma":0.0004114331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003131109,"about_ca_topic_score_gemma":0.0004541046,"domain_scores_codex":[0.9999139,0.00002474585,0.000007303727,0.00001574423,0.0000172561,0.00002096637],"domain_scores_gemma":[0.9999225,0.00001208277,0.0000246585,0.000007135849,0.00001453064,0.00001907633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001995421,0.0003415539,0.02000522,0.001916956,0.000184347,0.00170034,0.0001892426,0.001540993,0.6393687,0.004234334,0.002958633,0.3255643],"study_design_scores_gemma":[0.0004615647,0.007165464,0.1736614,0.001054297,0.001219186,0.0157155,0.001408012,0.01170262,0.5828244,0.01727032,0.1873045,0.0002126595],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.398589,0.5785952,0.009583118,0.005639509,0.0004257852,0.0000614028,0.0005140919,0.0002753416,0.006316583],"genre_scores_gemma":[0.8214478,0.1722188,0.002988201,0.0005970497,0.0002434663,0.00005745314,0.0004786523,0.00002674004,0.001941848],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.0006044218,"threshold_uncertainty_score":0.003899753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01470207878022123,"score_gpt":0.3019232934955992,"score_spread":0.287221214715378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}