{"id":"W4414779465","doi":"10.1038/s41467-025-64060-3","title":"A physiologically-relevant intermediate state structure of a voltage-gated potassium channel","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"British Columbia Knowledge Development Fund; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada; Heart and Stroke Foundation of Canada","keywords":"Helix (gastropod); Intermediate state; Ion channel; Potassium channel; Voltage-gated potassium channel; Protein structure; Ion; Linker","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007917156,0.0002047709,0.0001331529,0.00009023392,0.0002892447,0.0003713654,0.0002642187,0.0004546649,0.000984467],"category_scores_gemma":[0.0001555313,0.0001099432,0.0001711462,0.00007756436,0.0003013561,0.0004520747,0.0001923619,0.0005848779,0.0003312651],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003351283,"about_ca_system_score_gemma":0.0002296573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006059969,"about_ca_topic_score_gemma":0.0006757488,"domain_scores_codex":[0.999972,0.000002935201,0.000001623026,0.000009595001,0.000006837028,0.000007007933],"domain_scores_gemma":[0.9999299,0.000009591405,0.00001928789,0.000009811987,0.00001280449,0.00001863139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001326535,0.0000198343,0.001166885,0.0000574322,0.00001039122,0.0005265084,0.00007518656,0.00110775,0.9920369,0.002384595,0.00040165,0.002080187],"study_design_scores_gemma":[0.00006634101,0.0007498137,0.04491793,0.00005738572,0.0000632389,0.003625347,0.0003843083,0.01863405,0.8931291,0.007731802,0.03054813,0.00009245149],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810836,0.001277206,0.01341051,0.0003675363,0.00004979519,0.00001388021,0.0003730297,0.0002023243,0.003222067],"genre_scores_gemma":[0.9935234,0.0004619697,0.004105152,0.00007944744,0.00001136559,0.000008285452,0.0006841803,0.00001829774,0.001107918],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000984467,"threshold_uncertainty_score":0.003293335,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00980594041551636,"score_gpt":0.2752460440000675,"score_spread":0.2654401035845511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}