{"id":"W4414780426","doi":"10.1159/000548666","title":"Klotho, Kidneys, and Micronutrient Signaling: A Promising Paradigm for Healthy Aging","year":2025,"lang":"en","type":"article","venue":"Lifestyle Genomics","topic":"Parathyroid Disorders and Treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Klotho; Healthy aging; Biomarker; Longevity; Disease; Micronutrient; Cardiovascular health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001365524,0.0001595523,0.0002865861,0.0001040714,0.0001877145,0.00003921669,0.00004851538,0.00007165358,0.00000128388],"category_scores_gemma":[0.00004313355,0.0001519817,0.00006126129,0.00008765619,0.00004137176,0.00003504644,0.00003564939,0.00008506904,0.000004972057],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001265609,"about_ca_system_score_gemma":0.0003070668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003762028,"about_ca_topic_score_gemma":0.000006319061,"domain_scores_codex":[0.9990417,0.00001849322,0.0002500384,0.0003204418,0.00006020731,0.0003091721],"domain_scores_gemma":[0.9994518,0.00007883197,0.00007009616,0.0001986586,0.00002904857,0.0001716345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00827307,0.006050727,0.5540761,0.003117674,0.003287742,0.0002772851,0.01133628,0.0002686818,0.233644,0.03559281,0.106983,0.03709269],"study_design_scores_gemma":[0.03973188,0.002261497,0.01905075,0.0004248084,0.001282481,0.0001859079,0.000945185,0.00411247,0.04260901,0.01115817,0.8772746,0.0009632438],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9712185,0.01737065,0.004706924,0.004625424,0.0001755822,0.001251534,0.0000355224,0.00005440773,0.0005615033],"genre_scores_gemma":[0.9812789,0.0008958871,0.0116108,0.004551205,0.0001547393,0.0001241609,0.00009974098,0.00003572126,0.001248857],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7702916,"threshold_uncertainty_score":0.6197633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01480941384621328,"score_gpt":0.3029713275562454,"score_spread":0.2881619137100321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}