{"id":"W4414780426","doi":"10.1159/000548666","title":"Klotho, Kidneys, and Micronutrient Signaling: A Promising Paradigm for Healthy Aging","year":2025,"lang":"en","type":"article","venue":"Lifestyle Genomics","topic":"Parathyroid Disorders and Treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Klotho; Healthy aging; Biomarker; Longevity; Disease; Micronutrient; Cardiovascular health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004645822,0.0004880916,0.0007467221,0.0004915157,0.0003224098,0.001026127,0.0004686443,0.0008528392,0.002364972],"category_scores_gemma":[0.0003701515,0.00009474932,0.0003688418,0.0003342824,0.000664987,0.001312748,0.0007276842,0.001532901,0.0005233258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005186272,"about_ca_system_score_gemma":0.001418091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006513713,"about_ca_topic_score_gemma":0.00155254,"domain_scores_codex":[0.9998738,0.00002849666,0.00001422109,0.00002735025,0.00003439118,0.00002175752],"domain_scores_gemma":[0.9998192,0.00004947179,0.00002754901,0.000007078614,0.00005942579,0.00003730404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.000962479,0.0001539725,0.001678184,0.01733425,0.0002687235,0.001264491,0.0006615741,0.0005443034,0.07644326,0.05224568,0.06083336,0.7876099],"study_design_scores_gemma":[0.00004889723,0.0005355589,0.003973422,0.002068641,0.0002301561,0.001437979,0.0005302238,0.0003744449,0.006961224,0.02027771,0.9635131,0.00004860554],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003146296,0.9829051,0.002021906,0.006873185,0.002064387,0.00001228688,0.00009573107,0.00006415604,0.002816818],"genre_scores_gemma":[0.0231833,0.9652853,0.002027703,0.00293742,0.002635806,0.00003278803,0.0001484481,0.00001479878,0.003734378],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002364972,"threshold_uncertainty_score":0.007911563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01480941384621328,"score_gpt":0.3029713275562454,"score_spread":0.2881619137100321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}