{"id":"W4414784369","doi":"10.3390/cells14191548","title":"CES1 Increases Hepatic Triacylglycerol Synthesis Through Activation of PPARγ, LXR and SREBP1c","year":2025,"lang":"en","type":"article","venue":"Cells","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Alberta","funders":"Faculty of Medicine and Dentistry, University of Alberta; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Alberta","keywords":"Transfection; Gene knockdown; Liver X receptor; Lipid metabolism; Oleic acid; Lipid droplet; CD36; Fatty acid; Steatosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000197994,0.0006687212,0.0005043345,0.0004820493,0.0001552122,0.0003748246,0.0001711565,0.000310999,0.002281925],"category_scores_gemma":[0.0001825279,0.0002533094,0.000654154,0.0003757569,0.0002331316,0.0002366348,0.0003348965,0.0006338526,0.0005795247],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004512125,"about_ca_system_score_gemma":0.0002448775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006711566,"about_ca_topic_score_gemma":0.0008189412,"domain_scores_codex":[0.9998441,0.00002958985,0.00001714954,0.00003043393,0.00004193586,0.0000367367],"domain_scores_gemma":[0.999861,0.00001858565,0.00004379188,0.00001697899,0.00002646834,0.00003320403],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005829927,0.00003777034,0.0003198131,0.00009558572,0.00001827597,0.00005088953,0.00001880533,0.00008258468,0.9969619,0.00007284446,0.0001262487,0.001632333],"study_design_scores_gemma":[0.00005976631,0.000367994,0.00704182,0.00001048024,0.00004851437,0.0001747606,0.00004437382,0.0006075736,0.9883107,0.00005365966,0.003272006,0.000008316026],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986311,0.005017855,0.003685419,0.0005560963,0.0001026701,0.00004123079,0.001215523,0.0003654154,0.002704893],"genre_scores_gemma":[0.9833086,0.005086408,0.002822249,0.0002286755,0.00003923532,0.0000755639,0.002086214,0.00006987785,0.006283225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002281925,"threshold_uncertainty_score":0.007633805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006768669832157103,"score_gpt":0.2313156359793787,"score_spread":0.2245469661472216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}