{"id":"W4414784369","doi":"10.3390/cells14191548","title":"CES1 Increases Hepatic Triacylglycerol Synthesis Through Activation of PPARγ, LXR and SREBP1c","year":2025,"lang":"en","type":"article","venue":"Cells","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Alberta","funders":"Faculty of Medicine and Dentistry, University of Alberta; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Alberta","keywords":"Transfection; Gene knockdown; Liver X receptor; Lipid metabolism; Oleic acid; Lipid droplet; CD36; Fatty acid; Steatosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001278646,0.0001182086,0.0002003481,0.00004034544,0.00005151793,0.0000133769,0.0001126002,0.0001174482,0.000021173],"category_scores_gemma":[0.0002366516,0.0001001747,0.00006124126,0.00008285869,0.00007531009,0.000008484866,0.00007687256,0.00003284076,0.000003667016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004534767,"about_ca_system_score_gemma":0.0000590509,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009164242,"about_ca_topic_score_gemma":0.000004512812,"domain_scores_codex":[0.9992912,0.00007464336,0.00020035,0.0002320192,0.00007483662,0.0001268813],"domain_scores_gemma":[0.9994759,0.0001046277,0.00008763268,0.0002599085,0.00004161151,0.00003034254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009727582,0.000100846,0.001089033,0.0001171497,0.00007372873,2.158798e-7,0.00003104147,0.000001782559,0.9870802,0.0001432491,0.001051757,0.01021375],"study_design_scores_gemma":[0.0002731282,0.00002791347,0.002048382,0.00005461342,0.00007235427,3.700169e-7,0.00005297245,0.00001165897,0.9601521,0.0001218796,0.03710199,0.00008266563],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960555,0.001443558,0.0002902966,0.00007854715,0.0001134213,0.000147665,0.0000185367,0.000009017188,0.001843482],"genre_scores_gemma":[0.9972306,0.001059876,0.0008126796,0.0002196898,0.0001396707,0.00001819589,0.00001521711,0.000008966329,0.0004951257],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03605024,"threshold_uncertainty_score":0.4085005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006768669832157103,"score_gpt":0.2313156359793787,"score_spread":0.2245469661472216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}