{"id":"W4414787920","doi":"10.1371/journal.ppat.1013560","title":"West Nile virus vaccine candidates attenuated by dinucleotide enrichment are immunogenic and protective against lethal infection","year":2025,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Immunogenicity; CpG site; Interferon; Reversion; Virus; Amino acid; RNA; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001007194,0.0002491856,0.0004033672,0.0001261102,0.0001889205,0.00004131646,0.00006187393,0.0001024069,0.00011756],"category_scores_gemma":[0.0001498312,0.0002175881,0.000119115,0.0002886165,0.00003261281,0.00006886073,0.00007763576,0.000214964,0.00003926715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001596312,"about_ca_system_score_gemma":0.00008726042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004397371,"about_ca_topic_score_gemma":0.0001964452,"domain_scores_codex":[0.998665,0.00007715502,0.0002922687,0.0004450107,0.0001951461,0.0003254439],"domain_scores_gemma":[0.9991874,0.0000468679,0.0001267751,0.0003239969,0.0001573529,0.000157651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000669646,0.0006987815,0.2383233,0.0001989513,0.0006007159,0.00009137602,0.000117789,0.000005407187,0.74956,0.00001980311,0.002541599,0.007172647],"study_design_scores_gemma":[0.006089069,0.000595948,0.9216629,0.0005309312,0.001316371,0.00002176479,0.0002327699,0.001999986,0.06296139,0.00006494525,0.004092827,0.0004310536],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933864,0.003324506,0.0001079874,0.0007776697,0.0001081618,0.001308547,0.0003539695,0.0001310989,0.0005016663],"genre_scores_gemma":[0.9976972,0.000400859,0.00002010447,0.0007049501,0.00009468064,0.0003458354,0.0001968257,0.00002839187,0.0005111484],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6865986,"threshold_uncertainty_score":0.8872985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005798527899126076,"score_gpt":0.2334393604639696,"score_spread":0.2276408325648435,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}