{"id":"W4414787920","doi":"10.1371/journal.ppat.1013560","title":"West Nile virus vaccine candidates attenuated by dinucleotide enrichment are immunogenic and protective against lethal infection","year":2025,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Immunogenicity; CpG site; Interferon; Reversion; Virus; Amino acid; RNA; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001142849,0.0003890496,0.0002219211,0.0001403254,0.00008220597,0.000186383,0.0001930106,0.0001983428,0.0006775196],"category_scores_gemma":[0.0001039903,0.00009905256,0.0001542114,0.00008442381,0.0001159741,0.00015803,0.0001881638,0.0004542902,0.0001779101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000117411,"about_ca_system_score_gemma":0.00009720722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001956283,"about_ca_topic_score_gemma":0.000379392,"domain_scores_codex":[0.9998841,0.00001624033,0.00001089514,0.0000213968,0.00003282001,0.00003464716],"domain_scores_gemma":[0.9999534,0.0000067882,0.00001501556,0.000005365705,0.000007697087,0.00001173662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006530935,0.00002800379,0.0001474678,0.00001666056,0.000003096043,0.00001530743,0.000004082219,0.00008946152,0.9983439,0.00002689057,0.0000113675,0.001248376],"study_design_scores_gemma":[0.00002126738,0.001465703,0.003525934,0.000007377543,0.00003633706,0.0002667425,0.00002226347,0.0009399083,0.9916591,0.00004053716,0.002009397,0.000005438609],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962839,0.0005320676,0.002378293,0.00002791306,0.00001543318,0.00003232526,0.0001055405,0.00003446731,0.0005900017],"genre_scores_gemma":[0.9949596,0.0004562676,0.002913834,0.00004733077,0.000006962871,0.00003064806,0.0004238582,0.0000117284,0.001149835],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006775196,"threshold_uncertainty_score":0.002266526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005798527899126076,"score_gpt":0.2334393604639696,"score_spread":0.2276408325648435,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}