{"id":"W4414792234","doi":"10.1093/neuonc/noaf193.071","title":"OS09.5.A RECURRENT COPY NUMBER ALTERATIONS DRIVE IDH-MUTANT ASTROCYTOMA DEVELOPMENT AND PROGRESSION","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"","keywords":"Glioma; Astrocytoma; Tumor progression; Gene; Somatic cell; Anaplastic astrocytoma; PDGFRA; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001813716,0.0002917464,0.000253694,0.000509341,0.0002338233,0.0003921808,0.0002370444,0.0002133285,0.002567232],"category_scores_gemma":[0.0001581458,0.0001692947,0.0003206338,0.000399484,0.0002491123,0.00007714081,0.0002414475,0.0004389659,0.0006371174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003933406,"about_ca_system_score_gemma":0.0004936071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002916775,"about_ca_topic_score_gemma":0.008444369,"domain_scores_codex":[0.9998547,0.00001033376,0.00001664115,0.00004376314,0.00004255558,0.00003191311],"domain_scores_gemma":[0.9998839,0.00001565906,0.00004188941,0.0000131347,0.000008744097,0.00003674955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007199633,0.0002170693,0.01819101,0.0001250779,0.00007224863,0.0002133047,0.00004803795,0.001029965,0.9681177,0.000521592,0.000953365,0.009790727],"study_design_scores_gemma":[0.0002535942,0.00240619,0.246773,0.00003858386,0.0003880815,0.002299391,0.0002200307,0.01803671,0.7021985,0.0007718626,0.02657709,0.00003705827],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906089,0.0003834137,0.002074977,0.00007971045,0.00003419563,0.00004553383,0.004809985,0.0002082389,0.001754966],"genre_scores_gemma":[0.9881871,0.0002739033,0.002698023,0.0001020972,0.000005794497,0.00004930689,0.006853835,0.0000666616,0.00176324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002916775,"threshold_uncertainty_score":0.008588254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01893816173263653,"score_gpt":0.3463564281134819,"score_spread":0.3274182663808454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}