{"id":"W4414792344","doi":"10.1093/neuonc/noaf193.531","title":"P17.15.A ASSOCIATION OF PROTON PUMP INHIBITOR USE WITH OUTCOME OF PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"ATP Synthase and ATPases Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Temozolomide; Adverse effect; Radiation therapy; Clinical trial; O-6-methylguanine-DNA methyltransferase; Proton-pump inhibitor; Aldehyde dehydrogenase; Drug; Meta-analysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000142898,0.0001515971,0.00032368,0.0001052454,0.0000423845,0.00001010275,0.000166535,0.0002302118,0.00001576582],"category_scores_gemma":[0.0005807278,0.0001172515,0.00006578728,0.000236114,0.0001163249,0.00001056462,0.0001273468,0.000161962,0.000002626557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006952728,"about_ca_system_score_gemma":0.0002903667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005087476,"about_ca_topic_score_gemma":0.0002364879,"domain_scores_codex":[0.9986118,0.0001951199,0.0003368615,0.0003210841,0.0002692426,0.0002658582],"domain_scores_gemma":[0.9987188,0.0002108569,0.0003059919,0.0003037509,0.0003981625,0.00006246518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001869057,0.0004596053,0.6846405,0.00007059397,0.00008696272,0.00001309636,0.00002563465,0.00003735385,0.3106556,0.00001111491,0.0007219107,0.001408663],"study_design_scores_gemma":[0.005098076,0.00780373,0.08474596,0.00003842628,0.00006490526,9.408261e-7,0.00004595534,0.00002202053,0.8571864,0.000004862185,0.04483137,0.0001573022],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981801,0.00001613847,0.0001617853,0.0002454545,0.00008245176,0.000885752,0.00006375495,0.000009541411,0.0003550075],"genre_scores_gemma":[0.9989846,0.00002363602,0.0002360045,0.000279579,0.00005045522,0.0001213787,0.00005764929,0.00002038838,0.0002262664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5998945,"threshold_uncertainty_score":0.4781376,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01038101766363703,"score_gpt":0.2879060545253674,"score_spread":0.2775250368617304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}