{"id":"W4414796343","doi":"10.1002/oby.70051","title":"Topiramate Enhances <scp>GABAergic</scp> Tone to Orexigenic Neuropeptide Y/Agouti‐Related Peptide ( <scp>NPY</scp> / <scp>AgRP</scp> ) Neurons","year":2025,"lang":"en","type":"article","venue":"Obesity","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research; National Institutes of Health; Fonds de recherche du Québec; Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval; Canada First Research Excellence Fund; Canada Research Chairs; Fonds de Recherche du Québec - Santé; Fondation Institut Universitaire de Cardiologie et de Pneumologie de Québec","keywords":"Orexigenic; Topiramate; Arc (geometry); Neuropeptide; Tone (literature); GABAergic; Excitatory postsynaptic potential","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007031929,0.0003453394,0.000251361,0.0001500154,0.0001150133,0.0002136582,0.0002509386,0.0002660035,0.002715821],"category_scores_gemma":[0.0001267468,0.0001242058,0.0003481046,0.00007961613,0.0001363959,0.0001847372,0.00009705791,0.0006022318,0.0003777731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001926716,"about_ca_system_score_gemma":0.0001928657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008290195,"about_ca_topic_score_gemma":0.001598336,"domain_scores_codex":[0.9999471,0.000007715366,0.000005573166,0.00001041814,0.00001354148,0.00001559744],"domain_scores_gemma":[0.9999412,0.000009998137,0.00001660413,0.000006909364,0.000009034226,0.0000162743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005776177,0.0000999883,0.0001342973,0.0001034141,0.00002731782,0.00005214167,0.00001196029,0.0000619236,0.9951533,0.00004634446,0.0001032654,0.003628546],"study_design_scores_gemma":[0.000160165,0.003010998,0.009115762,0.00001097075,0.00009014995,0.0002559924,0.0000295816,0.001180196,0.9842827,0.00003864031,0.001816596,0.000008301791],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951366,0.001013632,0.000996654,0.00007838779,0.00004283123,0.00004126679,0.0003097106,0.0001593165,0.002221695],"genre_scores_gemma":[0.9955683,0.0008352182,0.001055571,0.00006120125,0.00001905312,0.00002866112,0.0002090444,0.00001428595,0.002208516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002715821,"threshold_uncertainty_score":0.009085357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01452091359275147,"score_gpt":0.2677095073318889,"score_spread":0.2531885937391374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}