{"id":"W4414799819","doi":"10.1093/neuonc/noaf193.070","title":"OS09.4.A EARLY TUMOR VOLUME CHANGES PREDICT CLINICAL OUTCOMES IN MIDH1/2 GLIOMA: POST-HOC RESULTS FROM THE PHASE 3 INDIGO TRIAL","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre; Toronto General Hospital","funders":"","keywords":"Confidence interval; Magnetic resonance imaging; Hazard ratio; Proportional hazards model; Placebo; Volume (thermodynamics); Isocitrate dehydrogenase; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005602219,0.001418223,0.001705077,0.0002976535,0.000278615,0.001283748,0.0008124932,0.000766872,0.003251046],"category_scores_gemma":[0.00320536,0.0003718137,0.002660538,0.0003462513,0.0008548081,0.0008354883,0.0005535231,0.002330119,0.0007256331],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005626037,"about_ca_system_score_gemma":0.001140244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007015477,"about_ca_topic_score_gemma":0.001481105,"domain_scores_codex":[0.9986879,0.0008844571,0.00004396248,0.0001756282,0.00008342788,0.0001246089],"domain_scores_gemma":[0.9980372,0.0007833398,0.0004317397,0.0002481411,0.0001162128,0.0003833238],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.9499499,0.004590007,0.01310271,0.0004199152,0.003167174,0.00004690723,0.00008006117,0.001924224,0.004918764,0.0001278866,0.002943655,0.01872872],"study_design_scores_gemma":[0.4234895,0.3630304,0.1715852,0.0001266297,0.01302312,0.0002919293,0.0002224795,0.0126954,0.00786533,0.001364255,0.006138123,0.0001675246],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915704,0.002229816,0.0005994722,0.0004427673,0.0001584071,0.0005621674,0.002886264,0.0001324635,0.001418327],"genre_scores_gemma":[0.9889026,0.0007570116,0.001291502,0.0005910373,0.0002267851,0.001093516,0.005039405,0.00007521523,0.002022961],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005602219,"threshold_uncertainty_score":0.02962774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04344044003611033,"score_gpt":0.3770198806953657,"score_spread":0.3335794406592554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}