{"id":"W4414800137","doi":"10.1093/neuonc/noaf193.011","title":"JS05.6.A EXPLORATORY ANALYSES FROM PHASE 3 INDIGO STUDY SUGGEST POTENTIAL MECHANISM OF SEIZURE CONTROL THROUGH TUMOR VOLUME REDUCTION UNDER TREATMENT WITH VORASIDENIB","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital","funders":"","keywords":"Placebo; Confidence interval; Glioma; Exploratory analysis; Astrocytoma; Brain tumor; Phases of clinical research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006410836,0.0007469983,0.001619262,0.0004798872,0.000309415,0.0008819703,0.0007262065,0.0005283542,0.00826533],"category_scores_gemma":[0.005200462,0.0002655461,0.004386946,0.0005336822,0.0004955858,0.000632566,0.0004074636,0.001304501,0.0006433639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005795907,"about_ca_system_score_gemma":0.001266711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005470706,"about_ca_topic_score_gemma":0.001705726,"domain_scores_codex":[0.9965688,0.002167359,0.0001815587,0.000436096,0.0003611277,0.0002850082],"domain_scores_gemma":[0.9960103,0.002247224,0.00071398,0.0004506177,0.0002275426,0.0003504003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6713727,0.005874419,0.1715199,0.00210914,0.01982831,0.0009972232,0.0002757974,0.006597681,0.0316027,0.001435451,0.01141323,0.07697345],"study_design_scores_gemma":[0.110386,0.2120744,0.5774946,0.0002360607,0.02583635,0.00205419,0.0004146947,0.0230651,0.02149999,0.003930429,0.02284733,0.0001608249],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9804088,0.002412608,0.002596471,0.0003578465,0.00007963266,0.001289995,0.008649452,0.0001457829,0.004059399],"genre_scores_gemma":[0.9889845,0.0003396335,0.00196651,0.000380133,0.00003964134,0.001222341,0.005175042,0.00003663292,0.001855564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00826533,"threshold_uncertainty_score":0.03390414,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0329219422620964,"score_gpt":0.3949904971785652,"score_spread":0.3620685549164688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}