{"id":"W4414800269","doi":"10.1093/neuonc/noaf193.404","title":"P12.25.B A GLOBAL PHASE 3, OPEN-LABEL, RANDOMIZED-CONTROLLED STUDY FOR NEWLY-DIAGNOSED, MGMT UNMETHYLATED GLIOBLASTOMA, COMPARING NIRAPARIB VS STANDARD OF CARE TEMOZOLOMIDE TREATMENT.","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Temozolomide; Phases of clinical research; Methyltransferase; Progressive disease; Standard of care; PARP inhibitor; Radiation therapy; Biomarker","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00181682,0.002049224,0.002462013,0.0005699745,0.000391837,0.0009944598,0.0009127468,0.002114438,0.02026794],"category_scores_gemma":[0.001275802,0.0006616486,0.001627059,0.0004337535,0.001130137,0.00100426,0.0003305417,0.003104733,0.002761325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000625592,"about_ca_system_score_gemma":0.001494531,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008810154,"about_ca_topic_score_gemma":0.001993837,"domain_scores_codex":[0.9994239,0.0003055196,0.00002432939,0.0001048014,0.00003614732,0.0001054167],"domain_scores_gemma":[0.9993148,0.0001485635,0.0001271872,0.0000413751,0.0000540323,0.0003139708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9769866,0.006386053,0.0003119081,0.0006937011,0.0006005857,0.00003713226,0.00001733546,0.0001555942,0.003014201,0.0001109021,0.002146574,0.009539315],"study_design_scores_gemma":[0.942604,0.05430278,0.001170841,0.00003173941,0.0002122095,0.00002473136,0.000007360842,0.0002036789,0.0002812537,0.0001260167,0.001025617,0.000009644616],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9162239,0.01098611,0.002221806,0.00265496,0.00192462,0.03982391,0.01445866,0.001092704,0.01061337],"genre_scores_gemma":[0.9356142,0.002953283,0.005413287,0.004121016,0.0006156618,0.03219308,0.005803404,0.0001200143,0.013166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02026794,"threshold_uncertainty_score":0.06780297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02781942778713061,"score_gpt":0.3807215949365066,"score_spread":0.3529021671493761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}