{"id":"W4414801201","doi":"10.1016/j.str.2025.09.005","title":"Allosteric regulation of fungal fatty acid synthesis","year":2025,"lang":"en","type":"article","venue":"Structure","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Canada Foundation for Innovation; Ontario Research Foundation; Princess Margaret Cancer Foundation","keywords":"Allosteric regulation; Reductase; Saccharomyces cerevisiae; Antifungal drug; Fatty acid; Enzyme; Moiety; Oxidoreductase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004903139,0.00009737819,0.0002229051,0.00008896181,0.0000356826,0.000006685074,0.00006508677,0.0001189632,0.0006276957],"category_scores_gemma":[0.0002074824,0.00006649575,0.00006732767,0.0002453589,0.00005021554,0.00003385328,0.00003060495,0.0001077737,0.000002843797],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002566932,"about_ca_system_score_gemma":0.00004262829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001207057,"about_ca_topic_score_gemma":0.000006341859,"domain_scores_codex":[0.9994197,0.00002255019,0.0001679106,0.0001794197,0.0001029887,0.0001074512],"domain_scores_gemma":[0.9995484,0.00002697941,0.00006182188,0.0002445242,0.00009141472,0.00002685891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001438734,0.00001010949,0.001748742,0.0001936965,0.0000554634,0.000001598081,0.00002755497,6.042103e-7,0.9636182,0.0003304338,0.002483547,0.03138615],"study_design_scores_gemma":[0.0001433741,0.00002271108,0.132042,0.0001162065,0.0001087942,0.00001394952,0.00001644395,0.000008399013,0.8642607,0.0004195309,0.002794461,0.00005346568],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935356,0.0004721921,0.00003377097,0.002991883,0.0002694355,0.0002132923,0.00004875737,0.00003058625,0.00240451],"genre_scores_gemma":[0.9968851,0.00001359507,0.001890816,0.0002710051,0.0001114854,3.075685e-7,0.00001229548,0.000006286994,0.0008091527],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1302933,"threshold_uncertainty_score":0.6872827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006840868791000542,"score_gpt":0.2356705486112765,"score_spread":0.2288296798202759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}