{"id":"W4414801201","doi":"10.1016/j.str.2025.09.005","title":"Allosteric regulation of fungal fatty acid synthesis","year":2025,"lang":"en","type":"article","venue":"Structure","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Canada Foundation for Innovation; Ontario Research Foundation; Princess Margaret Cancer Foundation","keywords":"Allosteric regulation; Reductase; Saccharomyces cerevisiae; Antifungal drug; Fatty acid; Enzyme; Moiety; Oxidoreductase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002560709,0.0001913636,0.0001605132,0.0001782698,0.0002434855,0.0006178389,0.0003332537,0.000261343,0.003355175],"category_scores_gemma":[0.0004520038,0.0001052391,0.0001832743,0.0001363081,0.0004817969,0.0003167861,0.0005033267,0.0004482492,0.0004085519],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005111434,"about_ca_system_score_gemma":0.0002133547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005585928,"about_ca_topic_score_gemma":0.001229965,"domain_scores_codex":[0.9998386,0.00004088727,0.000006833691,0.00002663662,0.00004407479,0.00004297201],"domain_scores_gemma":[0.9998615,0.00004145296,0.00002654974,0.00001967132,0.00001856772,0.00003224046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004845248,0.00008874022,0.0008481945,0.0001056055,0.00001001328,0.0001576043,0.0001243115,0.000583687,0.9619864,0.01886454,0.0006986825,0.01604778],"study_design_scores_gemma":[0.0001276878,0.0004068133,0.009430443,0.00004090436,0.00002183872,0.0005416279,0.0002902132,0.01589409,0.943969,0.01108559,0.01815231,0.00003939745],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9410114,0.006877413,0.01638843,0.002998396,0.0004552764,0.00004650868,0.0002239404,0.0004369378,0.0315618],"genre_scores_gemma":[0.9957249,0.0008507399,0.001480207,0.0001465277,0.00003574835,0.000006891407,0.00004810461,0.0000118696,0.001695009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003355175,"threshold_uncertainty_score":0.01122415,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006840868791000542,"score_gpt":0.2356705486112765,"score_spread":0.2288296798202759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}