{"id":"W4414803057","doi":"10.1101/2025.10.03.680238","title":"Stimulation of cholesterol efflux inhibits herpesvirus nuclear egress","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; University of Calgary; Dalhousie University","funders":"","keywords":"Lytic cycle; Viral membrane; Viral replication; Efflux; Nuclear transport; Intracellular; Cholesterol; Viral entry; Lipid bilayer fusion","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001407506,0.0003470574,0.0004145925,0.0001454888,0.0001207699,0.000340206,0.0001852196,0.0001710787,0.001413726],"category_scores_gemma":[0.0001449359,0.0001047837,0.000197141,0.0001297515,0.0001783328,0.0001517898,0.0002735644,0.0004395286,0.0003721614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002305971,"about_ca_system_score_gemma":0.0001932749,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005920451,"about_ca_topic_score_gemma":0.0007070144,"domain_scores_codex":[0.9998111,0.00003998582,0.00002318987,0.0000257217,0.00004888356,0.00005108059],"domain_scores_gemma":[0.9998822,0.00003194998,0.00002011692,0.00002262113,0.00001580533,0.00002713764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001756553,0.00004124121,0.00009544592,0.00003183493,0.000004922001,0.00001590084,0.00001148152,0.00002649662,0.9984093,0.00005296971,0.00003289422,0.001101831],"study_design_scores_gemma":[0.00001683936,0.000442141,0.001221697,0.000003450031,0.000007244403,0.00005076765,0.00001498239,0.0003296362,0.9963807,0.00002122485,0.001508766,0.000002541749],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938089,0.002678776,0.001438703,0.00008687469,0.00005955371,0.00003911621,0.0002861215,0.00007516585,0.001526794],"genre_scores_gemma":[0.9952409,0.0008782529,0.0008249616,0.00004276397,0.00001706961,0.00003841146,0.0004411099,0.00001341162,0.002503101],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001413726,"threshold_uncertainty_score":0.00472939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01557538420904218,"score_gpt":0.2578245521582938,"score_spread":0.2422491679492516,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}