{"id":"W4414804671","doi":"10.1016/j.jchf.2025.102660","title":"Semaglutide and Exercise Function in Obesity-Related HFpEF","year":2025,"lang":"en","type":"article","venue":"JACC Heart Failure","topic":"Cardiovascular Function and Risk Factors","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"National Institutes of Health; Tenax Therapeutics; Novo Nordisk; Cytokinetics; Congressionally Directed Medical Research Programs; National Institute on Aging; Amgen; Edwards Lifesciences; Eli Lilly and Company; GlaxoSmithKline; National Heart, Lung, and Blood Institute; U.S. Department of Defense","keywords":"Semaglutide; Heart failure; Type 2 diabetes; Obesity; Weight loss; Diabetes mellitus; Physical activity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002540231,0.0001250428,0.0003384119,0.0002826669,0.00007107131,0.00001885021,0.00002165305,0.000190039,0.0002067331],"category_scores_gemma":[0.00008102282,0.0001062512,0.000159672,0.0005047774,0.00003881029,0.00005399308,0.0000325107,0.0003225309,0.00009032765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006080687,"about_ca_system_score_gemma":0.00007803184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001729375,"about_ca_topic_score_gemma":0.0001295651,"domain_scores_codex":[0.9991375,0.0000502154,0.0002083788,0.0002661605,0.0001556589,0.0001820674],"domain_scores_gemma":[0.9995384,0.00003872073,0.00001804301,0.0002571117,0.00005060463,0.00009711517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001779394,0.000123204,0.934659,0.0001495898,0.0001271043,0.00002730106,0.0001591008,0.00002146243,0.00193121,0.0002496843,0.05263398,0.009740426],"study_design_scores_gemma":[0.001577438,0.00004117994,0.7303789,0.0002419119,0.0001448846,0.00003922065,0.000278716,0.00008737846,0.0004153268,0.00009981429,0.2666094,0.00008585255],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903666,0.001347445,0.0001192059,0.005847069,0.0004640757,0.0004544496,0.000001667567,0.0001270857,0.001272376],"genre_scores_gemma":[0.9935539,0.000141561,0.0002652936,0.0006578007,0.00004750497,0.00001553879,0.00001597963,0.00001263957,0.005289813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2139754,"threshold_uncertainty_score":0.4332796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004979706770497101,"score_gpt":0.2296490190430672,"score_spread":0.2246693122725701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}