{"id":"W4414806354","doi":"10.1101/2025.10.03.680348","title":"Cathepsin K as a Key Protease in Processing of SARS-CoV-2 Spike Activation Sites and a Target of Dual-Inhibition","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of Toronto; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; California HIV/AIDS Research Program","keywords":"Endosome; Proteases; Cathepsin; Cathepsin B; Cathepsin O; Cysteine protease; Protease; Cathepsin C; Cysteine; Cathepsin S","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000151739,0.0002521475,0.0002895203,0.00009278602,0.000132029,0.000381222,0.0001898705,0.0002630233,0.0008281036],"category_scores_gemma":[0.00008698262,0.0001092012,0.0003132304,0.0001022987,0.0002026414,0.0001409887,0.0001515594,0.0003654741,0.0002619484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004319486,"about_ca_system_score_gemma":0.0002519034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005554278,"about_ca_topic_score_gemma":0.0007443129,"domain_scores_codex":[0.9998776,0.00002115545,0.000009453868,0.00002051755,0.00004371671,0.00002763649],"domain_scores_gemma":[0.9999633,0.000004732823,0.00001232506,0.00000399732,0.000006170404,0.000009480971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002441639,0.00003665441,0.0006010698,0.00004126751,0.00001479067,0.0001091736,0.00001282883,0.0004257507,0.9963553,0.0002633817,0.00009030466,0.001805276],"study_design_scores_gemma":[0.0000524132,0.0003423443,0.007782479,0.000007285022,0.00002674366,0.001133448,0.00003387842,0.00654644,0.9796973,0.0001597837,0.004207361,0.00001059652],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933461,0.002458028,0.002032992,0.0001280654,0.00002014833,0.00002093647,0.0002096785,0.00005820386,0.001725878],"genre_scores_gemma":[0.9968609,0.0004740306,0.001521896,0.00003162937,0.000003994373,0.000006814249,0.0002135949,0.000004368699,0.0008828109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008281036,"threshold_uncertainty_score":0.003134072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01295837782223147,"score_gpt":0.2438100917061337,"score_spread":0.2308517138839022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}