{"id":"W4414807145","doi":"10.1016/j.gutmic.2025.100002","title":"Early-life gut microbiome and stress-axis perturbations dysregulate the development of systemic, mucosal, and brain immunity","year":2025,"lang":"en","type":"article","venue":"Gut Microbiology","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Alberta Health Services; McMaster University; Population Health Research Institute; Alberta Children's Hospital; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Crohn's and Colitis Canada; Canadian Institutes of Health Research; Mitacs; Marie Curie; Seventh Framework Programme; Molly Towell Perinatal Research Foundation; Norges Forskningsråd; Alberta Children's Hospital Research Institute; University of Ottawa","keywords":"Microbiome; Immune system; Gut–brain axis; Immunity; Gut flora; Phenotype; Inflammation; Human microbiome; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001683361,0.0006003043,0.0004593054,0.0003422954,0.0001954012,0.0004980435,0.0001842037,0.0003925596,0.000950725],"category_scores_gemma":[0.0002611806,0.0001862927,0.0003796234,0.0001491473,0.0004597812,0.0002612496,0.0005622513,0.001119754,0.0001824894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004022405,"about_ca_system_score_gemma":0.0005015742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008948765,"about_ca_topic_score_gemma":0.002208142,"domain_scores_codex":[0.9997196,0.0000399711,0.00001701056,0.00008611572,0.00006350882,0.00007382978],"domain_scores_gemma":[0.9997473,0.00001731921,0.000103173,0.00002065325,0.00002739098,0.00008411195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00077682,0.0000695909,0.005247112,0.0001498716,0.00005665351,0.0002049372,0.00007281236,0.0001612307,0.9840312,0.0003065553,0.0001965399,0.008726774],"study_design_scores_gemma":[0.00007597374,0.003232679,0.3716628,0.000211674,0.0002847118,0.001137212,0.0008060532,0.003047801,0.6056671,0.001607529,0.01218678,0.00007976458],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873164,0.005722822,0.004445476,0.0001992413,0.00008856932,0.00002603245,0.0009126703,0.0001557971,0.001132897],"genre_scores_gemma":[0.9908459,0.00360324,0.002956651,0.0002147331,0.00003115635,0.00007139762,0.0005711091,0.00003389086,0.001672016],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000950725,"threshold_uncertainty_score":0.003180504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008039437219365678,"score_gpt":0.247361216606878,"score_spread":0.2393217793875124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}