{"id":"W4414821271","doi":"10.1101/2025.10.02.680123","title":"Active mitochondria in healthy spiny mouse fibroblasts resemble megamitochondria and remain resilient across lifespan","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institutes of Health","keywords":"Mitochondrion; Stromal cell; Regeneration (biology); Phenotype; Wound healing; Developmental biology; Fibroblast; Mesenchymal stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002071119,0.0002907906,0.0001740161,0.0005565136,0.0002499867,0.000399471,0.0002271098,0.0003904401,0.00204189],"category_scores_gemma":[0.000135912,0.0001628179,0.0002046027,0.0002718515,0.000334599,0.0003426603,0.0002394299,0.00047047,0.0006490991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000125582,"about_ca_system_score_gemma":0.0001437991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000666743,"about_ca_topic_score_gemma":0.001407367,"domain_scores_codex":[0.9998049,0.00001249687,0.00003400892,0.00006810707,0.0000518321,0.0000287229],"domain_scores_gemma":[0.999712,0.00002403513,0.0001082389,0.00005322763,0.00003287174,0.00006954809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008266346,0.00001118748,0.0008695317,0.0000232107,0.000007342693,0.00009667796,0.00005667361,0.00001971343,0.9974819,0.0001559198,0.00003568508,0.001159581],"study_design_scores_gemma":[0.00002702666,0.0002940127,0.0620698,0.00002701721,0.00003334061,0.001787388,0.0002586783,0.0006748803,0.9279806,0.0004132273,0.006421319,0.00001280853],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819325,0.001425511,0.01170182,0.0002007113,0.00005738845,0.00004052766,0.001782201,0.0001835991,0.002675848],"genre_scores_gemma":[0.9867697,0.0007800545,0.004936502,0.0001079544,0.00001040012,0.0000668385,0.001541695,0.00006916574,0.005717698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00204189,"threshold_uncertainty_score":0.006830752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01175688103333514,"score_gpt":0.2628387000922837,"score_spread":0.2510818190589486,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}