{"id":"W4414823962","doi":"10.1016/j.nmd.2025.105573","title":"410PIntrathecal onasemnogene abeparvovec for treatment-experienced patients with spinal muscular atrophy: phase 3b, open-label STRENGTH study","year":2025,"lang":"en","type":"article","venue":"Neuromuscular Disorders","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; Montreal Children's Hospital","funders":"","keywords":"SMA*; Spinal muscular atrophy; Discontinuation; Tolerability; Motor function; Adverse effect; Activities of daily living; Population; Neuromuscular disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008424532,0.001078456,0.001926197,0.0003346443,0.0004329068,0.001014256,0.0007598306,0.001089656,0.005780096],"category_scores_gemma":[0.0005126931,0.000391981,0.001403677,0.000305523,0.0007952512,0.0007523749,0.0002798983,0.002692091,0.0009709755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006606486,"about_ca_system_score_gemma":0.001241841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001732437,"about_ca_topic_score_gemma":0.005341135,"domain_scores_codex":[0.9997265,0.00009335374,0.00001125481,0.00004420615,0.00002882192,0.00009593282],"domain_scores_gemma":[0.9997037,0.00005101829,0.00005967418,0.00002792784,0.00002620932,0.0001313571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7570644,0.1068717,0.002769419,0.001391408,0.002913391,0.0001289952,0.0001944466,0.001398022,0.02536937,0.0004485727,0.004327032,0.09712327],"study_design_scores_gemma":[0.5834321,0.4057394,0.005805807,0.00008663325,0.0006135696,0.00009820382,0.00008130931,0.0006812404,0.001416561,0.0002040014,0.001814414,0.00002679793],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936413,0.001728484,0.0003861159,0.0002601693,0.0001736783,0.00134691,0.0008180745,0.00006420289,0.001581075],"genre_scores_gemma":[0.9848592,0.003320201,0.0013165,0.001061774,0.0002374437,0.002579994,0.001802476,0.00002935619,0.004793112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005780096,"threshold_uncertainty_score":0.01933634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03049668498102193,"score_gpt":0.3865635582746631,"score_spread":0.3560668732936412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}