{"id":"W4414823962","doi":"10.1016/j.nmd.2025.105573","title":"410PIntrathecal onasemnogene abeparvovec for treatment-experienced patients with spinal muscular atrophy: phase 3b, open-label STRENGTH study","year":2025,"lang":"en","type":"article","venue":"Neuromuscular Disorders","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; Montreal Children's Hospital","funders":"","keywords":"SMA*; Spinal muscular atrophy; Discontinuation; Tolerability; Motor function; Adverse effect; Activities of daily living; Population; Neuromuscular disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001816693,0.0006666289,0.0009050923,0.0003428417,0.000493144,0.0002047483,0.0006527916,0.0001341719,0.00009311045],"category_scores_gemma":[0.00015756,0.0005238419,0.000328501,0.0008482258,0.0002824344,0.0001808142,0.0002324489,0.0002224162,0.00001672814],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001409178,"about_ca_system_score_gemma":0.000589236,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001993029,"about_ca_topic_score_gemma":0.0001864384,"domain_scores_codex":[0.995993,0.0002330769,0.0005501387,0.001450166,0.0008350373,0.0009385851],"domain_scores_gemma":[0.9978064,0.00007225438,0.0001228879,0.001306141,0.000301179,0.0003911749],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.03810149,0.1772649,0.1507589,0.0007290056,0.005650963,0.000409534,0.001626078,0.0001289603,0.0143173,0.001116841,0.001209156,0.6086868],"study_design_scores_gemma":[0.5117568,0.1816373,0.1588674,0.0003795533,0.004750246,0.00002338891,0.004720796,0.002980216,0.005820201,0.000444503,0.1260502,0.002569349],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846154,0.0006371124,0.001791548,0.0006809863,0.0001988972,0.01106147,0.00005504474,0.0001064651,0.000853012],"genre_scores_gemma":[0.9952501,0.0002196532,0.001019879,0.0005278612,0.0000500662,0.001983017,0.0002375639,0.0001237245,0.0005881459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6061174,"threshold_uncertainty_score":0.9997213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03049668498102193,"score_gpt":0.3865635582746631,"score_spread":0.3560668732936412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}