{"id":"W4414824026","doi":"10.1016/j.nmd.2025.106021","title":"98PStnf-rii restores leptin homeostasis in human adipocytes exposed to plasma from sporadic ALS patients with fast progressing disease","year":2025,"lang":"nl","type":"article","venue":"Neuromuscular Disorders","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"","keywords":"Leptin; Downregulation and upregulation; Secretion; Immune system; Homeostasis; Adipokine; Agonist; Endogeny","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002378895,0.0009143102,0.001240668,0.001004115,0.0004025261,0.0001725724,0.0005664781,0.0002561251,0.0004029019],"category_scores_gemma":[0.0004929651,0.0008507521,0.0003112431,0.001523187,0.00038907,0.000327702,0.000253547,0.0007227437,0.000212564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001609833,"about_ca_system_score_gemma":0.0004325542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008621265,"about_ca_topic_score_gemma":0.0009877805,"domain_scores_codex":[0.9946945,0.000459056,0.0009708951,0.001614871,0.001058931,0.001201783],"domain_scores_gemma":[0.9970676,0.0001738919,0.0003109074,0.001415024,0.0001580171,0.0008745723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002769875,0.003069643,0.8518937,0.0005259386,0.0007071264,0.0005438713,0.002692357,0.0003095832,0.001710403,0.00016426,0.003028635,0.1325847],"study_design_scores_gemma":[0.01117479,0.0007627817,0.9386107,0.002716663,0.001514296,5.155703e-7,0.0007591904,0.00009632183,0.0007559383,0.0001280402,0.04264339,0.0008373964],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9759979,0.01733099,0.00005837336,0.001698912,0.0007067678,0.003136952,0.0002069202,0.0001545695,0.0007086296],"genre_scores_gemma":[0.9956391,0.0005390947,0.000331693,0.001027543,0.0001959647,0.0002118795,0.0005955271,0.0001827481,0.001276474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1317473,"threshold_uncertainty_score":0.9993943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009169842880803535,"score_gpt":0.2555536389180803,"score_spread":0.2463837960372767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}