{"id":"W4414824323","doi":"10.1016/j.euroneuro.2025.08.291","title":"T8. INSULIN ASSOCIATED VENTRAL TEGMENTAL AREA EXPRESSION-BASED POLYGENIC SCORE PREDICTS ADULT PSYCHIATRIC-CARDIOMETABOLIC COMORBIDITY AFTER PRENATAL ADVERSITY","year":2025,"lang":"en","type":"article","venue":"European Neuropsychopharmacology","topic":"Birth, Development, and Health","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Douglas Mental Health University Institute; McGill University","funders":"","keywords":"Ventral tegmental area; Impulsivity; Brain stimulation reward; Dopaminergic; Polygenic risk score; Gestational diabetes; CREB1; Candidate gene; Offspring; Obesity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003182398,0.0005506644,0.0002668529,0.0006874121,0.0003841406,0.0005741505,0.0003675179,0.000499737,0.006976611],"category_scores_gemma":[0.0009916872,0.0001310462,0.0007869682,0.0006434228,0.0002076705,0.0001958959,0.0004484036,0.0005752356,0.0005080141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002531221,"about_ca_system_score_gemma":0.0002397847,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007717982,"about_ca_topic_score_gemma":0.006176873,"domain_scores_codex":[0.9997483,0.00005190851,0.00002323804,0.0001023653,0.00003047995,0.00004367484],"domain_scores_gemma":[0.9993538,0.0001079253,0.0002625074,0.00004681429,0.00003390538,0.0001950145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005399815,0.00005282865,0.993656,0.00001682503,0.000329061,0.0001967347,0.00003244006,0.000270065,0.001976809,0.00008384579,0.0003462639,0.002499111],"study_design_scores_gemma":[0.0000084624,0.0001072466,0.9972056,0.000007092211,0.000108068,0.0004277125,0.00003539872,0.001636488,0.0001933955,0.0001125572,0.0001541315,0.000003825892],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964705,0.0001384085,0.0005364055,0.00007610547,0.00001384829,0.00001089748,0.001941739,0.00002485248,0.0007872508],"genre_scores_gemma":[0.9980195,0.00003581542,0.0002815305,0.0000156743,0.000006571135,0.00001524411,0.0009293372,0.000006851574,0.000689439],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007717982,"threshold_uncertainty_score":0.02333909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01498699457093841,"score_gpt":0.2818553105134811,"score_spread":0.2668683159425427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}