{"id":"W4414824413","doi":"10.1016/j.euroneuro.2025.08.431","title":"W72. GENOME-WIDE MULTI-TRAIT GENOMIC AND TRANSCRIPTOMIC ANALYSES OF SMOKING BEHAVIOURS AND SCHIZOPHRENIA REVEAL NEW BIOLOGICAL INSIGHTS AND OPPORTUNITIES FOR DRUG REPURPOSING","year":2025,"lang":"en","type":"article","venue":"European Neuropsychopharmacology","topic":"Health, Environment, Cognitive Aging","field":"Environmental Science","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre for Addiction and Mental Health; University of Toronto","funders":"","keywords":"Genome-wide association study; Context (archaeology); Expression quantitative trait loci; Transcriptome; Genetic association; Drug repositioning; Nicotine; Gene; Schizophrenia (object-oriented programming)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004062407,0.0005507898,0.0004193276,0.000562852,0.0003903199,0.0005209288,0.000311526,0.0007307878,0.008268653],"category_scores_gemma":[0.0006243745,0.0001805446,0.00069874,0.0007796536,0.0002643097,0.0002476224,0.0004073785,0.0007093401,0.0007806895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001967,"about_ca_system_score_gemma":0.0005408154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009248872,"about_ca_topic_score_gemma":0.01787844,"domain_scores_codex":[0.9997635,0.00003480395,0.00001660557,0.00008096338,0.00004096589,0.00006317419],"domain_scores_gemma":[0.999676,0.00006657371,0.000101732,0.0000321404,0.00004168938,0.00008179231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.006523557,0.0003606603,0.2168707,0.000737325,0.003134188,0.003872758,0.0003777108,0.001761003,0.6262451,0.003225303,0.0136907,0.123201],"study_design_scores_gemma":[0.0002729154,0.0004248373,0.9480412,0.0001027886,0.0008165858,0.001471244,0.0002195366,0.002432728,0.0250567,0.003654714,0.01742797,0.00007872544],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9554474,0.004503821,0.008690772,0.003794509,0.0004667791,0.00007451846,0.02041229,0.0003859702,0.00622411],"genre_scores_gemma":[0.9775378,0.001414483,0.003781586,0.0013571,0.000143985,0.0000589685,0.006786889,0.0001568227,0.008762273],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009248872,"threshold_uncertainty_score":0.02766138,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07592420277947609,"score_gpt":0.3272222087208795,"score_spread":0.2512980059414034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}