{"id":"W4414824667","doi":"10.1016/j.euroneuro.2025.08.259","title":"M63. GENOSTAR: A BIOINFORMATICS R PACKAGE FOR STAR ALLELE CALLING ACROSS KEY CYP GENES","year":2025,"lang":"en","type":"article","venue":"European Neuropsychopharmacology","topic":"Genetics, Bioinformatics, and Biomedical Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"","keywords":"Genotyping; Genotype; CYP2D6; Allele; Pharmacogenomics; Pharmacogenetics; Concordance","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002863196,0.003375419,0.00284578,0.001817199,0.0009672362,0.002184224,0.002813042,0.001228804,0.0696141],"category_scores_gemma":[0.009103166,0.001635176,0.002812074,0.001379393,0.0006413699,0.001040522,0.001805376,0.002408575,0.0437269],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006798131,"about_ca_system_score_gemma":0.001980916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003048084,"about_ca_topic_score_gemma":0.005919969,"domain_scores_codex":[0.998928,0.0003726811,0.00008297767,0.0003503653,0.0001470904,0.0001188298],"domain_scores_gemma":[0.9970793,0.00192434,0.0002439695,0.000359754,0.0002479339,0.0001446783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003093453,0.0002590296,0.01666612,0.003805034,0.002753581,0.0007644597,0.0009251207,0.01178965,0.02316214,0.01224451,0.794931,0.129606],"study_design_scores_gemma":[0.003518523,0.0006433948,0.01859808,0.0005637738,0.002071816,0.001649308,0.0003012926,0.1720359,0.05703653,0.05750646,0.6853019,0.0007730444],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"software","genre_gemma":"software","genre_scores_codex":[0.01157073,0.0007066309,0.3344752,0.0005537472,0.0004329615,0.0003277963,0.1305084,0.5159758,0.005448742],"genre_scores_gemma":[0.05329271,0.0005642709,0.579479,0.001414922,0.0002047517,0.001998969,0.1122607,0.238549,0.01223574],"genre_candidate":"software","genre_consensus":"software","teacher_disagreement_score":0.0696141,"threshold_uncertainty_score":0.2328824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02078180936864217,"score_gpt":0.3317112436194729,"score_spread":0.3109294342508307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}