{"id":"W4414825108","doi":"10.1016/j.carbpol.2025.124493","title":"Methylation in ambient ion source enables direct isomer differentiation of oligosaccharides by tandem mass spectrometry","year":2025,"lang":"en","type":"article","venue":"Carbohydrate Polymers","topic":"Mass Spectrometry Techniques and Applications","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China","keywords":"Trisaccharide; Tandem mass spectrometry; Tandem; Mass spectrometry; Tetramethylammonium hydroxide; Fragmentation (computing); Structural isomer; Methylation; Ion trap; Tetramethylammonium","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004153334,0.0005897133,0.0002291606,0.0003939047,0.0001881017,0.0003292946,0.0003970955,0.000520062,0.0009568476],"category_scores_gemma":[0.000445266,0.000265578,0.0002261944,0.0002600614,0.0003522109,0.0005793894,0.0005495845,0.0008080932,0.0005901631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000261753,"about_ca_system_score_gemma":0.0002479455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003330132,"about_ca_topic_score_gemma":0.0005679503,"domain_scores_codex":[0.9996535,0.00004567433,0.00001515713,0.0001299401,0.0001120425,0.00004376463],"domain_scores_gemma":[0.9998522,0.00003179373,0.00004000951,0.00001912868,0.00003961804,0.00001728307],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003650051,0.000007212452,0.0001864423,0.00002995872,0.000005969397,0.00003088569,0.00001464154,0.00004310563,0.9949044,0.0001528255,0.00006857998,0.004519412],"study_design_scores_gemma":[0.000006114984,0.00007218511,0.001016832,0.000005265828,0.0000134381,0.0002889172,0.00001821097,0.002283531,0.993339,0.0001570313,0.002786528,0.00001294792],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.7301869,0.005294209,0.2535364,0.0004541709,0.0001806745,0.0001879996,0.001048622,0.001626382,0.007484739],"genre_scores_gemma":[0.8219333,0.002946181,0.1694554,0.0003897802,0.00006921015,0.0001314834,0.0006278296,0.0001957468,0.004251164],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.0009568476,"threshold_uncertainty_score":0.003200948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006952122107243669,"score_gpt":0.2367681955499901,"score_spread":0.2298160734427464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}